6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone

Base Information

Chemical Name:6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone
CAS No.:958457-36-8
Molecular Formula:C₂₀H₁₆F₃NO₄
Molecular Weight:391.347
Hs Code.:

Synonyms:6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone

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Chemical Property of 6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone

Chemical Property:

Purity/Quality:

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Technology Process of 6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone

There total 10 articles about 6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 958457-34-6
6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyran-4(1H)-one

: 958457-36-8
6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone

Guidance literature:: With ammonia; In ethanol; water; at 140 ℃;
DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 958457-36-8
6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / water / 20 °C

2: hydrogenchloride; zinc / water / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

5: ammonia / ethanol; water / 140 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; ammonia; sodium carbonate; potassium carbonate; sodium hydroxide; zinc; In ethanol; water; N,N-dimethyl-formamide; toluene; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

: 958457-41-5
(4-(4-(trifluoromethoxy)phenoxy)phenyl)boronic acid

: 958457-36-8
6-hydroxymethyl-2-methyl-3-(4-{4-[(trifluoromethyl)oxy]phenyl}oxy)-pyridinone

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

2: ammonia / ethanol; water / 140 °C

With bis-triphenylphosphine-palladium(II) chloride; ammonia; sodium carbonate; In ethanol; water; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.07.044