(4-chloro-2-hydroxymethyl-phenyl)-carbamic acid ethyl ester

Base Information

• Chemical Name: (4-chloro-2-hydroxymethyl-phenyl)-carbamic acid ethyl ester
• CAS No.: 1202681-60-4
• Molecular Formula: C₁₀H₁₂ClNO₃
• Molecular Weight: 229.663
• Mol file: 1202681-60-4.mol

Synonyms:(4-chloro-2-hydroxymethyl-phenyl)-carbamic acid ethyl ester

Chemical Property of (4-chloro-2-hydroxymethyl-phenyl)-carbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (4-chloro-2-hydroxymethyl-phenyl)-carbamic acid ethyl ester

There total 2 articles about (4-chloro-2-hydroxymethyl-phenyl)-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-5-chlorobenzyl alcohol (37585-25-4) + chloroformic acid ethyl ester (541-41-3) → (4-chloro-2-hydroxymethyl-phenyl)-carbamic acid ethyl ester (1202681-60-4)

Guidance literature:

With pyridine; In dichloromethane; for 1h;

Reference yield:

5-chloroanthranilic acid (635-21-2) → (4-chloro-2-hydroxymethyl-phenyl)-carbamic acid ethyl ester (1202681-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2: sodium carbonate / tetrahydrofuran / 12 h / 20 °C

With lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran;

DOI:10.1021/acs.orglett.5b02279

Reference yield: 84.0%

(4-chloro-2-hydroxymethyl-phenyl)-carbamic acid ethyl ester (1202681-60-4) → ethyl (4-chloro-2-formylphenyl)carbamate

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2.5h; diastereoselective reaction;

DOI:10.1021/acs.orglett.8b00237

upstream raw materials:

2-amino-5-chlorobenzyl alcohol

chloroformic acid ethyl ester

5-chloroanthranilic acid