1-(2,2-difluorovinyl)-4-benzene carboxylic acid methyl ester

Base Information

• Chemical Name: 1-(2,2-difluorovinyl)-4-benzene carboxylic acid methyl ester
• CAS No.: 1022094-52-5
• Molecular Formula: C₁₀H₈F₂O₂
• Molecular Weight: 198.169
• Mol file: 1022094-52-5.mol

Synonyms:1-(2,2-difluorovinyl)-4-benzene carboxylic acid methyl ester

Chemical Property of 1-(2,2-difluorovinyl)-4-benzene carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1-(2,2-difluorovinyl)-4-benzene carboxylic acid methyl ester

There total 16 articles about 1-(2,2-difluorovinyl)-4-benzene carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxycarbonylphenyl bromide (619-42-1) + C9H8F2O3SZn → 1-(2,2-difluorovinyl)-4-benzene carboxylic acid methyl ester (1022094-52-5)

Guidance literature:

With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; at 90 ℃; for 16h;

DOI:10.1021/acscatal.0c03993

Reference yield: 90.0%

4-methoxycarbonylphenyl bromide (619-42-1) + toluene-4-sulfonic acid 2,2-difluorovinyl ester (185739-14-4) → 1-(2,2-difluorovinyl)-4-benzene carboxylic acid methyl ester (1022094-52-5)

Guidance literature:

With [2,2]bipyridinyl; nickel dichloride; zinc; In N,N-dimethyl acetamide; at 90 ℃; for 16h; Reagent/catalyst;

DOI:10.1021/acscatal.0c03993

Reference yield: 80.0%

methyl 4-iodobenzoate (619-44-3) + toluene-4-sulfonic acid 2,2-difluorovinyl ester (185739-14-4) → 1-(2,2-difluorovinyl)-4-benzene carboxylic acid methyl ester (1022094-52-5)

Guidance literature:

With [2,2]bipyridinyl; nickel dichloride; zinc; In N,N-dimethyl acetamide; at 90 ℃; for 16h;

DOI:10.1021/acscatal.0c03993

upstream raw materials:

methyl 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate

toluene-4-sulfonic acid 2,2-difluorovinyl ester

dibromodifluoromethane

methyl 4-formylbenzoate

Downstream raw materials:

4-(2,2,2-trifluoroethyl)benzaldehyde