2,2-Difluoroethenyl 4-methylbenzene-1-sulfonate

Base Information

Chemical Name:2,2-Difluoroethenyl 4-methylbenzene-1-sulfonate
CAS No.:185739-14-4
Molecular Formula:C₉H₈F₂O₃S
Molecular Weight:234.224
Hs Code.:
European Community (EC) Number:851-979-3
Nikkaji Number:J973.667K

Synonyms:185739-14-4;2,2-difluoroethenyl 4-methylbenzene-1-sulfonate;2,2-Difluorovinyl 4-methylbenzenesulfonate;2,2-difluoroethenyl 4-methylbenzenesulfonate;2,2-di-fluorovinyltosylate;2,2-difluorovinyl tosylate;Toluene-4-sulfonic acid 2,2-difluoro-vinyl ester;2,2-difluoroethenyl tosylate;C9H8F2O3S;SCHEMBL343964;BCP31148;AKOS040768317;AT27893;BS-52555;CS-0311591;2,2-difluoroethenyl4-methylbenzene-1-sulfonate;EN300-243851;p-Toluenesulfonic acid 2,2-difluorovinyl ester;Toluene-4-sulfonic acid 2,2-difluorovinyl ester;toluene-4-sulfonic acid 2, 2-difluorovinyl ester;A1-21944;2,2-Di-fluorovinyltosylate;2,2-Difluoroethenyl tosylate

Suppliers and Price of 2,2-Difluoroethenyl 4-methylbenzene-1-sulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 6 raw suppliers

Chemical Property of 2,2-Difluoroethenyl 4-methylbenzene-1-sulfonate

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:234.01622161
Heavy Atom Count:15
Complexity:320

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OC=C(F)F

Technology Process of 2,2-Difluoroethenyl 4-methylbenzene-1-sulfonate

There total 3 articles about 2,2-Difluoroethenyl 4-methylbenzene-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 433-06-7
2,2,2-Trifluoroethyl p-toluenesulfonate

: 185739-14-4
toluene-4-sulfonic acid 2,2-difluorovinyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -65 ℃; for 0.5h;

Reference yield: 79.0%

: 591-50-4
iodobenzene

: 1256278-61-1
2,2-difluoro-1-tributylstannylethenyl p-toluenesulfonate

: 1256278-62-2
2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate

: 185739-14-4
toluene-4-sulfonic acid 2,2-difluorovinyl ester

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ol1024037

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 185739-14-4
toluene-4-sulfonic acid 2,2-difluorovinyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / diethyl ether / 48 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C

2.2: 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1039/c2ob25802a