benzyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate

Base Information

Chemical Name:benzyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate
CAS No.:1418150-23-8
Molecular Formula:C₂₃H₂₄FN₅O₂S₂
Molecular Weight:485.606
Hs Code.:

Synonyms:benzyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate

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Chemical Property of benzyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate

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Technology Process of benzyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate

There total 4 articles about benzyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 1418150-29-4
(1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl piperazine-1-carbodithioate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1418150-23-8
benzyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate

Guidance literature:: With potassium carbonate; In dichloromethane; at 20 ℃; for 7h;
DOI:10.1021/jm401002r

Reference yield:

: 1418150-12-5
tert-butyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate

: 1418150-23-8
benzyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2: potassium carbonate / dichloromethane / 20 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2012.12.046

Reference yield:

: 1418150-39-6
tert-butyl-4-((prop-2-yn-1-ylthio)carbonothioyl)piperazine-1-carboxylate

: 1418150-23-8
benzyl 4-(((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methylthio)carbonothioyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tetrahydrofuran; water / 20 °C

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3: potassium carbonate / dichloromethane / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2012.12.046