7-[cis-4-aminomethyl-4-(3-chlorophenyl)cyclohexyl]-3-trifluoromethyl-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one

Base Information

Chemical Name:7-[cis-4-aminomethyl-4-(3-chlorophenyl)cyclohexyl]-3-trifluoromethyl-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
CAS No.:1037361-18-4
Molecular Formula:C₁₉H₂₁ClF₃N₅O
Molecular Weight:427.857
Hs Code.:

Synonyms:7-[cis-4-aminomethyl-4-(3-chlorophenyl)cyclohexyl]-3-trifluoromethyl-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one

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Chemical Property of 7-[cis-4-aminomethyl-4-(3-chlorophenyl)cyclohexyl]-3-trifluoromethyl-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one

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Technology Process of 7-[cis-4-aminomethyl-4-(3-chlorophenyl)cyclohexyl]-3-trifluoromethyl-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one

There total 8 articles about 7-[cis-4-aminomethyl-4-(3-chlorophenyl)cyclohexyl]-3-trifluoromethyl-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: C₂₄H₃₂ClF₃IN₅O₇

: 1037361-18-4
7-[cis-4-aminomethyl-4-(3-chlorophenyl)cyclohexyl]-3-trifluoromethyl-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.12.118

Reference yield:

: 1037235-38-3
[1-(cis-3-chlorophenyl)-4-(8-oxo-3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)cyclohexylmethyl]carbamic acid tert-butyl ester

: 1037361-18-4
7-[cis-4-aminomethyl-4-(3-chlorophenyl)cyclohexyl]-3-trifluoromethyl-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one

Guidance literature:: With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

Reference yield:

: 65619-29-6
1-(3-chlorophenyl)-4-oxocyclohexanecarbonitrile

: 1037361-18-4
7-[cis-4-aminomethyl-4-(3-chlorophenyl)cyclohexyl]-3-trifluoromethyl-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one

Guidance literature:: Multi-step reaction with 7 steps

1: toluene-4-sulfonic acid / toluene / 18 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 - 50 °C

3: triethylamine / dichloromethane / 4 h / 20 °C

4: pyridinium p-toluenesulfonate / acetone; water / 48 h / Reflux

5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; acetic acid / 5 h / 20 °C

6: ruthenium dioxide dihydrate; sodium periodate / chloroform; acetonitrile; water / 0.33 h / 20 °C

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium periodate; lithium aluminium tetrahydride; ruthenium dioxide dihydrate; pyridinium p-toluenesulfonate; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; water; acetic acid; 1,2-dichloro-ethane; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2013.12.118