4,5-bis(trifluoromethyl)-3-fluorophthalamide

Base Information

Chemical Name:4,5-bis(trifluoromethyl)-3-fluorophthalamide
CAS No.:1374136-23-8
Molecular Formula:C₁₀H₅F₇N₂O₂
Molecular Weight:318.151
Hs Code.:

Synonyms:4,5-bis(trifluoromethyl)-3-fluorophthalamide

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Chemical Property of 4,5-bis(trifluoromethyl)-3-fluorophthalamide

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Technology Process of 4,5-bis(trifluoromethyl)-3-fluorophthalamide

There total 8 articles about 4,5-bis(trifluoromethyl)-3-fluorophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1374136-21-6
4,5-bis(trifluoromethyl)-3-fluorophthalimide

: 1374136-23-8
4,5-bis(trifluoromethyl)-3-fluorophthalamide

Guidance literature:: With ammonium hydroxide; for 18h;

Reference yield:

: 95-47-6
o-xylene

: 1374136-23-8
4,5-bis(trifluoromethyl)-3-fluorophthalamide

Guidance literature:: Multi-step reaction with 8 steps

1: iodine; sulfuric acid; periodic acid / water; acetic acid / 18 h / 70 °C

2: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 22 h / 20 - 165 °C / Inert atmosphere

3: nitric acid; sulfuric acid / 3 h / 60 °C

4: cesium fluoride / N,N-dimethyl-formamide / 70 h / 20 - 120 °C / Inert atmosphere

5: chromium(VI) oxide; sulfuric acid / acetic acid / 20.5 h / 15 - 35 °C

6: thionyl chloride / 3 h / 90 °C

7: urea / 2 h / 140 °C

8: ammonium hydroxide / 18 h

With chromium(VI) oxide; ammonium hydroxide; copper(l) iodide; thionyl chloride; sulfuric acid; iodine; nitric acid; periodic acid; cesium fluoride; urea; In 1-methyl-pyrrolidin-2-one; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 5182-67-2
1,2-diiodo-4,5-dimethyl-benzene

: 1374136-23-8
4,5-bis(trifluoromethyl)-3-fluorophthalamide

Guidance literature:: Multi-step reaction with 7 steps

1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 22 h / 20 - 165 °C / Inert atmosphere

2: nitric acid; sulfuric acid / 3 h / 60 °C

3: cesium fluoride / N,N-dimethyl-formamide / 70 h / 20 - 120 °C / Inert atmosphere

4: chromium(VI) oxide; sulfuric acid / acetic acid / 20.5 h / 15 - 35 °C

5: thionyl chloride / 3 h / 90 °C

6: urea / 2 h / 140 °C

7: ammonium hydroxide / 18 h

With chromium(VI) oxide; ammonium hydroxide; copper(l) iodide; thionyl chloride; sulfuric acid; nitric acid; cesium fluoride; urea; In 1-methyl-pyrrolidin-2-one; acetic acid; N,N-dimethyl-formamide;