4,5-bis(trifluoromethyl)-3-fluorophthalonitrile

Base Information

Chemical Name:4,5-bis(trifluoromethyl)-3-fluorophthalonitrile
CAS No.:1374136-24-9
Molecular Formula:C₁₀HF₇N₂
Molecular Weight:282.12
Hs Code.:

Synonyms:4,5-bis(trifluoromethyl)-3-fluorophthalonitrile

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Chemical Property of 4,5-bis(trifluoromethyl)-3-fluorophthalonitrile

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Technology Process of 4,5-bis(trifluoromethyl)-3-fluorophthalonitrile

There total 7 articles about 4,5-bis(trifluoromethyl)-3-fluorophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1374136-23-8
4,5-bis(trifluoromethyl)-3-fluorophthalamide

: 1374136-24-9
4,5-bis(trifluoromethyl)-3-fluorophthalonitrile

Guidance literature:: With thionyl chloride; In N,N-dimethyl-formamide; at -10 - 20 ℃;

Reference yield:

: 5182-67-2
1,2-diiodo-4,5-dimethyl-benzene

: 1374136-24-9
4,5-bis(trifluoromethyl)-3-fluorophthalonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 22 h / 20 - 165 °C / Inert atmosphere

2: nitric acid; sulfuric acid / 3 h / 60 °C

3: cesium fluoride / N,N-dimethyl-formamide / 70 h / 20 - 120 °C / Inert atmosphere

4: chromium(VI) oxide; sulfuric acid / acetic acid / 20.5 h / 15 - 35 °C

5: thionyl chloride / 3 h / 90 °C

6: urea / 2 h / 140 °C

7: ammonium hydroxide / 18 h

8: thionyl chloride / N,N-dimethyl-formamide / -10 - 20 °C

With chromium(VI) oxide; ammonium hydroxide; copper(l) iodide; thionyl chloride; sulfuric acid; nitric acid; cesium fluoride; urea; In 1-methyl-pyrrolidin-2-one; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 2341-35-7
1,2-dimethyl-4,5-bis(trifluoromethyl)benzene

: 1374136-24-9
4,5-bis(trifluoromethyl)-3-fluorophthalonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid; sulfuric acid / 3 h / 60 °C

2: cesium fluoride / N,N-dimethyl-formamide / 70 h / 20 - 120 °C / Inert atmosphere

3: chromium(VI) oxide; sulfuric acid / acetic acid / 20.5 h / 15 - 35 °C

4: thionyl chloride / 3 h / 90 °C

5: urea / 2 h / 140 °C

6: ammonium hydroxide / 18 h

7: thionyl chloride / N,N-dimethyl-formamide / -10 - 20 °C

With chromium(VI) oxide; ammonium hydroxide; thionyl chloride; sulfuric acid; nitric acid; cesium fluoride; urea; In acetic acid; N,N-dimethyl-formamide;