5,7-dichloro-1H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: 5,7-dichloro-1H-imidazo[4,5-b]pyridine
• CAS No.: 24485-01-6
• Molecular Formula: C6H3Cl2N3
• Molecular Weight: 188.016
• Hs Code.: 2933990090
• European Community (EC) Number: 810-080-6
• NSC Number: 264046
• DSSTox Substance ID: DTXSID30421446
• Nikkaji Number: J1.160.658J
• Mol file: 24485-01-6.mol

Synonyms:5,7-dichloro-1H-imidazo[4,5-b]pyridine;24485-01-6;5,7-DICHLORO-3H-IMIDAZO[4,5-B]PYRIDINE;5,7-Dichloroimidazo[4,5-b]pyridine;3H-IMIDAZO[4,5-B]PYRIDINE, 5,7-DICHLORO-;1H-Imidazo[4,5-b]pyridine, 5,7-dichloro-;MFCD11111407;SCHEMBL2316808;DTXSID30421446;IKJFWUNKUZVHGU-UHFFFAOYSA-N;BCP32528;FD7016;FD7030;NSC264046;AKOS006308469;AKOS037643648;AB68866;CS-W005069;NSC-264046;AS-19755;SY046620;FT-0647025;EN300-312505;A817334;J-516555;5,7-Dichloro-1H-imidazo[4,5-b]pyridine

Chemical Property of 5,7-dichloro-1H-imidazo[4,5-b]pyridine

Chemical Property:

• Vapor Pressure: 0.00936mmHg at 25°C
• Melting Point: 273-274 °C
• Refractive Index: 1.768
• Boiling Point: 416.867 °C at 760 mmHg
• PKA: 5.37±0.40(Predicted)
• Flash Point: 238.425 °C
• PSA: 41.57000
• Density: 1.675 g/cm³
• LogP: 2.26470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 186.9704025
• Heavy Atom Count: 11
• Complexity: 155

Purity/Quality:

98%, ^*data from raw suppliers

5,7-Dichloro-1H-imidazo[4,5-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C2=C(N=CN2)N=C1Cl)Cl

Technology Process of 5,7-dichloro-1H-imidazo[4,5-b]pyridine

There total 13 articles about 5,7-dichloro-1H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

7-nitro-1H-imidazo[4,5-b]pyridine 4-oxide (14432-11-2) → 5,7-dichloro-3H-imidazo<4,5-b>pyrimidine (24485-01-6)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 0 - 120 ℃; for 3h;

Reference yield: 80.0%

7-nitroimidazo<4,5-b>pyridine-4-oxide (14432-11-2) → 5,7-dichloro-3H-imidazo<4,5-b>pyrimidine (24485-01-6)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1021/jm0607956

Reference yield: 46.0%

C6H4ClN3O → 5,7-dichloro-1H-imidazo[4,5-b]pyridine (24485-01-6)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; for 2.5h; Reflux;

upstream raw materials:

7-Amino-3H-imidazo<4,5-b>pyridine 4-N-Oxide

7-nitro-1H-imidazo[4,5-b]pyridine 4-oxide

7-nitroimidazo<4,5-b>pyridine-4-oxide

3H-Imidazo<4,5-b>pyridine 4-N-oxide

Downstream raw materials:

5,7-dichloro-3-(2,3-dideoxy-5-O-p-toluoyl-β-D-glycero-pentofuranosyl)-3H-imidazo<4,5-b>pyridine

3-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-D-ribofuranosyl)-5,7-dichloro-3H-imidazo[4,5-b]pyridine

3-benzyl-5,7-diphenyl-3H-imidazo[4,5-b]pyridine

5,7-dichloro-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-imidazo[4,5-b]pyridine