3H-Imidazo[4,5-b]pyridine, 7-nitro-, 4-oxide

Base Information

• Chemical Name: 3H-Imidazo[4,5-b]pyridine, 7-nitro-, 4-oxide
• CAS No.: 14432-11-2
• Molecular Formula: C6H4 N4 O3
• Molecular Weight: 180.123
• Hs Code.: 2933990090
• Mol file: 14432-11-2.mol

Synonyms:1H-Imidazo[4,5-b]pyridine,7-nitro-, 4-oxide (8CI,9CI)

Chemical Property of 3H-Imidazo[4,5-b]pyridine, 7-nitro-, 4-oxide

Chemical Property:

• Melting Point: 289 °C (decomp)
• Boiling Point: 602.4±58.0 °C(Predicted)
• PKA: 3.94±0.40(Predicted)
• PSA: 99.96000
• Density: 1.89±0.1 g/cm3(Predicted)
• LogP: 1.42280

Purity/Quality:

99% ^*data from raw suppliers

7-Nitro-1H-imidazo[4,5-b]pyridine4-oxide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-Imidazo[4,5-b]pyridine, 7-nitro-, 4-oxide

There total 6 articles about 3H-Imidazo[4,5-b]pyridine, 7-nitro-, 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3H-Imidazo<4,5-b>pyridine 4-N-oxide (6863-46-3) → 7-nitroimidazo<4,5-b>pyridine-4-oxide (14432-11-2)

Guidance literature:

With nitric acid; In trifluoroacetic acid; at 90 ℃; for 3h;

DOI:10.1002/jps.2600730319

Reference yield: 39.4%

Imidazo<4,5-b>pyridine 4-Oxide (6863-46-3) → 7-nitro-1H-imidazo[4,5-b]pyridine 4-oxide (14432-11-2)

Guidance literature:

With nitric acid; In trifluoroacetic acid; at 0 - 90 ℃; for 3.5h;

Reference yield:

3H-imidazo[4,5-b]pyridine (273-21-2) → 7-nitroimidazo<4,5-b>pyridine-4-oxide (14432-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / aq. H₂O₂; acetic acid / 19 h / 60 - 70 °C

2: 67 percent / trifluoroacetic acid; HNO₃ / 3 h / 90 °C

With dihydrogen peroxide; nitric acid; acetic acid; trifluoroacetic acid;

DOI:10.1021/jm0607956

upstream raw materials:

3H-Imidazo<4,5-b>pyridine 4-N-oxide

3H-imidazo[4,5-b]pyridine

2,3-Diaminopyridine

1H-Imidazo[4,5-b]pyridine

Downstream raw materials:

2,6-dichloro-9-benzyl-1-deazapurine

3-benzyl-5,7-diphenyl-3H-imidazo[4,5-b]pyridine

5,7-dichloro-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-imidazo[4,5-b]pyridine

3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholino-3H-imidazo[4,5-b]pyridin-7-ol