tricyclo<3.3.1.1^3,7>dec-2-yl -<2--1-(1H-indol-3-ylmethyl)-1-methylethyl>carbamate

Base Information

• Chemical Name: tricyclo<3.3.1.1^3,7>dec-2-yl -<2--1-(1H-indol-3-ylmethyl)-1-methylethyl>carbamate
• CAS No.: 139657-25-3
• Molecular Formula: C₃₃H₄₁N₃O₃
• Molecular Weight: 527.707

Synonyms:tricyclo<3.3.1.1^3,7>dec-2-yl -<2--1-(1H-indol-3-ylmethyl)-1-methylethyl>carbamate

Chemical Property of tricyclo<3.3.1.1^3,7>dec-2-yl -<2--1-(1H-indol-3-ylmethyl)-1-methylethyl>carbamate

Chemical Property:

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Technology Process of tricyclo<3.3.1.1^3,7>dec-2-yl -<2--1-(1H-indol-3-ylmethyl)-1-methylethyl>carbamate

There total 2 articles about tricyclo<3.3.1.1^3,7>dec-2-yl -<2--1-(1H-indol-3-ylmethyl)-1-methylethyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tricyclo<3.3.1.13,7>dec-2-yl <1-(1H-indol-3-ylmethyl)-1-methyl-2-<(2-phenylethyl)amino>ethyl>carbamate (139657-24-2) + acetyl chloride (75-36-5) → tricyclo<3.3.1.13,7>dec-2-yl -<2--1-(1H-indol-3-ylmethyl)-1-methylethyl>carbamate (139657-25-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1021/jm00086a017

Reference yield:

tricyclo[3.3.1.13,7]dec-2-yl (R)-{1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl}carbamate (130406-43-8) → tricyclo<3.3.1.13,7>dec-2-yl -<2--1-(1H-indol-3-ylmethyl)-1-methylethyl>carbamate (139657-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 14 percent / lithium borohydride, chlorotrimethylsilane / tetrahydrofuran / 20 h / Ambient temperature

2: 85 percent / triethylamine / CH₂Cl₂ / 0.33 h / 0 °C

With lithium borohydride; chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00086a017

upstream raw materials:

tricyclo<3.3.1.1^3,7>dec-2-yl <1-(1H-indol-3-ylmethyl)-1-methyl-2-<(2-phenylethyl)amino>ethyl>carbamate

acetyl chloride

tricyclo[3.3.1.1^3,7]dec-2-yl (R)-{1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl}carbamate

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