2-Hydroxy-3-phenoxypropyl acetate

Base Information

• Chemical Name: 2-Hydroxy-3-phenoxypropyl acetate
• CAS No.: 63715-95-7
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• DSSTox Substance ID: DTXSID00980055
• Nikkaji Number: J90.338H
• Mol file: 63715-95-7.mol

Synonyms:63715-95-7;3-Phenoxy-1,2-propanediol 1-acetate;1-Acetyloxy-3-phenoxy-2-propanol;1-Phenyl-ether-3-acetate glycerol;2-Propanol, 1-acetyloxy-3-phenoxy-;1,2-Propanediol, 3-phenoxy-, 1-acetate;2-hydroxy-3-phenoxypropyl acetate;SCHEMBL6351413;1-Acetoxy-3-phenoxy-2-propanol;DTXSID00980055;1-acetoxy-2-hydroxy-3-phenoxypropane;LS-120701;1,3-Benzenedimethanamine, N,N'-bis(2-chloroethyl)-

Chemical Property of 2-Hydroxy-3-phenoxypropyl acetate

Chemical Property:

• Vapor Pressure: 1.13E-05mmHg at 25°C
• Boiling Point: 355.6°C at 760 mmHg
• Flash Point: 137.3°C
• PSA: 55.76000
• Density: 1.162g/cm³
• LogP: 0.98940
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 210.08920892
• Heavy Atom Count: 15
• Complexity: 187

Purity/Quality:

99.0%min ^*data from raw suppliers

2-HYDROXY-3-PHENOXYPROPYL ACETIC ACID ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OCC(COC1=CC=CC=C1)O

Technology Process of 2-Hydroxy-3-phenoxypropyl acetate

There total 15 articles about 2-Hydroxy-3-phenoxypropyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Phenyl glycidyl ether (122-60-1,71031-02-2) + acetic acid (64-19-7,77671-22-8) → 1-O-acetyl-3-(phenoxy)propane-1,2-diol (63715-95-7,147220-19-7)

Guidance literature:

With tin(IV)tetraphenylporphyrinato trifluoromethanesulfonate; for 0.583333h; Heating;

DOI:10.1016/j.tet.2004.05.069

Reference yield: 98.0%

vinyl acetate (108-05-4,9003-20-7) + 3-phenoxy-1,2-propanediol (538-43-2) → 1-O-acetyl-3-(phenoxy)propane-1,2-diol (63715-95-7,147220-19-7)

Guidance literature:

With porcine pancreatic lipase; In di-isopropyl ether; at 20 ℃; for 3h; regioselective reaction; Enzymatic reaction;

DOI:10.1007/s00706-011-0688-y

Reference yield: 92.0%

Phenyl glycidyl ether (122-60-1,71031-02-2) + sodium acetate (127-09-3) → 1-O-acetyl-3-(phenoxy)propane-1,2-diol (63715-95-7,147220-19-7)

Guidance literature:

With Fe₃O₄(at)SiO₂/N,N-bis(triethoxysilylpropyl)-4,4-bipyridinium dichloride nanocomposite; In water; at 90 ℃; for 1.5h; regioselective reaction; Green chemistry;

DOI:10.1016/j.crci.2015.06.019

upstream raw materials:

(RS)-1-chloro-3-phenyloxy-2-propanol

3-phenoxy-1,2-propanediol

acetic anhydride

acetyl chloride

Downstream raw materials:

2-Methoxy-1-acetoxy-3-phenoxy-propan

1,2-di-O-acetyl-3-(phenoxy)propane-1,2-diol

1-hydroxy-3-phenoxy-2-propanone

(S)-1-acetoxy-3-phenoxypropan-2-ol