3'-Azido-3'-deoxythymidine-5'-triphosphate

Base Information

• Chemical Name: 3'-Azido-3'-deoxythymidine-5'-triphosphate
• CAS No.: 92586-35-1
• Molecular Formula: C₁₀H₁₆N₅O₁₃P₃
• Molecular Weight: 507.184
• Mol file: 92586-35-1.mol

Synonyms:3'-Azido-3'-deoxythymidine5'-triphosphate; 3'-Azido-3'-deoxythymidine triphosphate; 3'-Azidothymidinetriphosphate; AZT triphosphate; AZTTP; Azidothymidine triphosphate; Zidovudine5'-triphosphate; Zidovudine triphosphate

Chemical Property of 3'-Azido-3'-deoxythymidine-5'-triphosphate

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 303.09000
• Density: g/cm³
• LogP: -0.39254

Purity/Quality:

98%Min ^*data from raw suppliers

AZTtriphosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-Azido-3'-deoxythymidine-5'-triphosphate

There total 3 articles about 3'-Azido-3'-deoxythymidine-5'-triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) → Zidovudine triphosphate (92586-35-1)

Guidance literature:

3'-azido-2',3'-deoxythymidine; With triethyl phosphate; trichlorophosphate; at -10 ℃; for 2h;

With tributyl-amine; triethyl phosphate; tri(n-butyl)ammonium pyrophosphate; In N,N-dimethyl-formamide; for 0.0833333h;

DOI:10.1081/NCN-100002084

Reference yield:

3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) → Zidovudine triphosphate (92586-35-1) + 3'-azido-3'-deoxythymidine 5'-<β,γ-imido>triphosphate (141171-21-3)

Guidance literature:

With sodium hydroxide; tributyl-amine; triethyl phosphate; trichlorophosphate; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jm00089a002

Reference yield:

tetradecanoyl 3'-azido-3'-deoxy-5'-thymidinyltriphosphate → Zidovudine triphosphate (92586-35-1)

Guidance literature:

With water; triethylammonium acetate; at 37 ℃; pH 7.0; degradation kinetics: half-life 150 h; further nucleotides and conditions;

DOI:10.1021/jo951354p

upstream raw materials:

3'-azido-2',3'-deoxythymidine