2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline
CAS No.:1269261-75-7
Molecular Formula:C₁₇H₁₇BrClNO₂S
Molecular Weight:414.75
Hs Code.:

Synonyms:2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Suppliers and Price of 2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

There total 5 articles about 2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269261-57-5
N-(2-(but-3-en-1-yl)-6-chlorophenyl)-4-methylbenzenesulfonamide

: 1269261-75-7
2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: With palladium diacetate; potassium carbonate; copper(ll) bromide; In tetrahydrofuran; at 25 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.tet.2010.12.017

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1269261-75-7
2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 12 h / Inert atmosphere; Reflux

2: thionyl chloride / dichloromethane / 12 h / 0 °C / Inert atmosphere; Reflux

3: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4: palladium diacetate; potassium carbonate; copper(ll) bromide / tetrahydrofuran / 72 h / 25 °C / Inert atmosphere

With pyridine; thionyl chloride; palladium diacetate; potassium carbonate; copper(ll) bromide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2010.12.017

Reference yield:

: 1252576-10-5
N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide

: 1269261-75-7
2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 12 h / 0 °C / Inert atmosphere; Reflux

2: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3: palladium diacetate; potassium carbonate; copper(ll) bromide / tetrahydrofuran / 72 h / 25 °C / Inert atmosphere

With thionyl chloride; palladium diacetate; potassium carbonate; copper(ll) bromide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2010.12.017