N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide
• CAS No.: 1252576-10-5
• Molecular Formula: C₁₄H₁₄ClNO₃S
• Molecular Weight: 311.789
• Mol file: 1252576-10-5.mol

Synonyms:N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide

Chemical Property of N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide

There total 4 articles about N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(2-amino-3-chlorophenyl)methanol (61487-25-0) + p-toluenesulfonyl chloride (98-59-9) → N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide (1252576-10-5)

Guidance literature:

With pyridine; In dichloromethane; for 12h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2010.12.017

Reference yield:

2-amino-3-chlorobenzoic acid (6388-47-2) → N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide (1252576-10-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / water / 3 h / 60 - 85 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran; water;

DOI:10.1021/jo402132p

Reference yield:

C14H12ClNO4S → N-(6-chloro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide (1252576-10-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo402132p

upstream raw materials:

(2-amino-3-chlorophenyl)methanol

p-toluenesulfonyl chloride

2-amino-3-chlorobenzoic acid

Downstream raw materials:

N-(2-chloro-6-(chloromethyl)phenyl)-4-methylbenzenesulfonamide

N-(6-chloro-2-formylphenyl)-4-methylbenzenesulfonamide

2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

N-(2-(but-3-en-1-yl)-6-chlorophenyl)-4-methylbenzenesulfonamide