tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate

Base Information

Chemical Name:tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate
CAS No.:1072002-52-8
Molecular Formula:C₂₂H₂₇N₃O₄
Molecular Weight:397.474
Hs Code.:

Synonyms:tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate

Suppliers and Price of tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate

There total 5 articles about tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 657432-27-4
[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-yl]methanol

: 1072002-52-8
tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate

Guidance literature:: In isopropyl alcohol;

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1072002-52-8
tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl acetamide / 24 h / 0 - 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 24 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / Reflux

4: isopropyl alcohol / 16 h

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2018.09.006

Reference yield:

: 3096-70-6
3,5-dimethyl-4-aminophenol

: 1072002-52-8
tert-butyl (4-{[2-(hydroxymethyl)-1-methyl-1H-benzimidazol-6-yl]oxy}-2,6-dimethylphenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl acetamide / 24 h / 0 - 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 24 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / Reflux

4: isopropyl alcohol / 16 h

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2018.09.006