(S)-(-)-1,2-Diaminopropane dihydrochloride

Base Information

• Chemical Name: (S)-(-)-1,2-Diaminopropane dihydrochloride
• CAS No.: 19777-66-3
• Molecular Formula: C₃H₁₂N₂*2Cl
• Molecular Weight: 147.048
• Hs Code.: 29212900
• Mol file: 19777-66-3.mol

Synonyms:(S)-(-)-Diaminopropane Hydrochloride;1,2-Propanediamine,dihydrochloride, (S)-;1,2-Propanediamine, dihydrochloride, L- (8CI);

Chemical Property of (S)-(-)-1,2-Diaminopropane dihydrochloride

Chemical Property:

• Vapor Pressure: 0.12mmHg at 25°C
• Melting Point: 227-229 °C
• Boiling Point: 215.8 °C at 760 mmHg
• Flash Point: 84.3 °C
• PSA: 52.04000
• LogP: 2.29690
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

99%min ^*data from raw suppliers

(S)-(?)-1,2-Diaminopropane dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, T
• Hazard Codes: Xi,T
• Statements: 36/37/38-23/24/25
• Safety Statements: 26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-(-)-1,2-Diaminopropane Dihydrochloride is used in the synthesis of Dexrazoxane, a cardiac medicine. (S)-(-)-1,2-Diaminopropane dihydrochloride may be used in the preparation of following chiral imidazoline derivatives, which show moderate α-adrenergic blocking activity:(S)-(-)-4-methyl-2-(1-naphthylmethyl)imidazoline hydrochloride(S)-(-)-2-benzyl-4-methylimidazoline picrate(S )-(-)-2-[(2,6-dichlorophenyl)imino]-4-methylimidazolidine hydrochloride

Technology Process of (S)-(-)-1,2-Diaminopropane dihydrochloride

There total 15 articles about (S)-(-)-1,2-Diaminopropane dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-methyl-imidazolidin-2-one (6531-31-3) → (racemi)-1,2-diaminopropane dihydrochloride (19777-66-3,19777-67-4,20267-34-9,41889-20-7,62036-75-3)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 0.0333333h; microwave irradiation;

DOI:10.1080/00397910701464951

Reference yield: 97.0%

1-azido-2-aminopropane → (racemi)-1,2-diaminopropane dihydrochloride (19777-66-3,19777-67-4,20267-34-9,41889-20-7,62036-75-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 3102.9 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)91013-0

Reference yield: 95.0%

[Ni(1,2-diaminopropane)2Cl2]*3H2O + salicylaldehyde (90-02-8) → [Ni(OC6H4CHNCH2CH(CH3)NCHC6H4O)]*0.5H2O + (racemi)-1,2-diaminopropane dihydrochloride (19777-66-3,19777-67-4,20267-34-9,41889-20-7,62036-75-3)

Guidance literature:

In ethanol; soln. of org. compd. added to soln. of complex, refluxed for 3 h; allowed to cool slowly to room temp., filtered, washed with EtOH and Et2O, air-dried, elem. anal.;

DOI:10.1081/SIM-100105251

upstream raw materials:

4-methyl-imidazolidin-2-one

salicylaldehyde

1,2-diaminopropan

(S)-tert-butyl 1-aminopropan-2-ylcarbamate

Downstream raw materials:

(4S)-2-benzyl-4-methyl-4,5-dihydro-1H-imidazole

(R)-2-Benzyl-4-methyl-4,5-dihydro-1H-imidazole

(2S)-[N,N'-bis(2'-hydroxy-3',5'-di-tert-butylbenzylidene)]-1,2-diaminopropane

(2S)-[N,N'-bis(2'-hydroxybenzylidene)]-1,2-diaminopropane

Refernces

• 1、 Petersen, Johannes F.,Tortzen, Christian G.,Pittelkow, Michael,Christensen, J?rn B.. "Synthesis and properties of chiral internally branched PAMAM-dendrimers". . p. 1109 - 1116. Retrieved 2015.
• 2、 Abdel-Aal, Seham K.,Kandeel, Mohamed F.,El-Sherif, Ashraf F.,Abdel-Rahman, Ahmed S.. "Synthesis, Characterization, and Optical Properties of New Organic–Inorganic Hybrid Perovskites [(NH3)2(CH2)3]CuCl4 and [(NH3)2(CH2)4]CuCl2Br . . Retrieved 2021/05/03.
• 3、 -. "Dexrazoxane preparation method". Paragraph 0016-0017; 0020-0021. . Retrieved 2019/07/04.