rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester

Base Information

Chemical Name:rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester
CAS No.:1326706-85-7
Molecular Formula:C₁₁H₉F₃INO₃
Molecular Weight:387.097
Hs Code.:

Synonyms:rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester

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Chemical Property of rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester

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Technology Process of rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester

There total 6 articles about rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1070773-68-0
2-amino-2-(2'-iodophenyl)acetic acid methyl ester

: 407-25-0
trifluoroacetic anhydride

: 1326706-85-7
rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2011.06.001

Reference yield:

: 1326706-98-2
2-amino-2-(2'-iodophenyl) acetic acid hydrochloride

: 1326706-85-7
rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 16 h / 0 - 20 °C

2: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; thionyl chloride; In dichloromethane;
DOI:10.1016/j.bmc.2011.06.001

Reference yield:

: α-amino-o-iodophenylacetonitrile

: 1326706-85-7
rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / 1 h / Reflux

2: thionyl chloride / 16 h / 0 - 20 °C

3: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; water; In dichloromethane;
DOI:10.1016/j.bmc.2011.06.001