rac-2-(2-isopropenyl-phenyl)-2-(2,2,2-trifluoroacetylamino)acetic acid methyl ester

Base Information

Chemical Name:rac-2-(2-isopropenyl-phenyl)-2-(2,2,2-trifluoroacetylamino)acetic acid methyl ester
CAS No.:1326706-87-9
Molecular Formula:C₁₄H₁₄F₃NO₃
Molecular Weight:301.265
Hs Code.:

Synonyms:rac-2-(2-isopropenyl-phenyl)-2-(2,2,2-trifluoroacetylamino)acetic acid methyl ester

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Chemical Property of rac-2-(2-isopropenyl-phenyl)-2-(2,2,2-trifluoroacetylamino)acetic acid methyl ester

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Technology Process of rac-2-(2-isopropenyl-phenyl)-2-(2,2,2-trifluoroacetylamino)acetic acid methyl ester

There total 11 articles about rac-2-(2-isopropenyl-phenyl)-2-(2,2,2-trifluoroacetylamino)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1326706-99-3
2-amino-2-(2-isopropenylphenyl)acetic acid methyl ester

: 407-25-0
trifluoroacetic anhydride

: 1326706-87-9
rac-2-(2-isopropenyl-phenyl)-2-(2,2,2-trifluoroacetylamino)acetic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2011.06.001

Reference yield: 83.0%

: 1326706-85-7
rac-(2-iodo-phenyl)-2,2,2-trifluoroacetylaminoacetic acid methyl ester

: 126726-62-3
2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1326706-87-9
rac-2-(2-isopropenyl-phenyl)-2-(2,2,2-trifluoroacetylamino)acetic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; toluene; at 80 ℃; for 24h;
DOI:10.1016/j.bmc.2011.06.001

Reference yield:

: 1326706-98-2
2-amino-2-(2'-iodophenyl) acetic acid hydrochloride

: 1326706-87-9
rac-2-(2-isopropenyl-phenyl)-2-(2,2,2-trifluoroacetylamino)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 16 h / 0 - 20 °C

2: pyridine / dichloromethane / 12 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water; toluene / 24 h / 80 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; In tetrahydrofuran; dichloromethane; water; toluene; 3: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmc.2011.06.001