isopropyl 4-benzyl-2-ethyl-7-fluoro-3,4-dihydro-3-oxoquinoxaline-1(2H)-carboxylate

Base Information

Chemical Name:isopropyl 4-benzyl-2-ethyl-7-fluoro-3,4-dihydro-3-oxoquinoxaline-1(2H)-carboxylate
CAS No.:1345694-43-0
Molecular Formula:C₂₁H₂₃FN₂O₃
Molecular Weight:370.424
Hs Code.:

Synonyms:isopropyl 4-benzyl-2-ethyl-7-fluoro-3,4-dihydro-3-oxoquinoxaline-1(2H)-carboxylate

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Chemical Property of isopropyl 4-benzyl-2-ethyl-7-fluoro-3,4-dihydro-3-oxoquinoxaline-1(2H)-carboxylate

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Technology Process of isopropyl 4-benzyl-2-ethyl-7-fluoro-3,4-dihydro-3-oxoquinoxaline-1(2H)-carboxylate

There total 4 articles about isopropyl 4-benzyl-2-ethyl-7-fluoro-3,4-dihydro-3-oxoquinoxaline-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1-benzyl-3-ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one

: 108-23-6
isopropyl chloroformate

: 1345694-43-0
isopropyl 4-benzyl-2-ethyl-7-fluoro-3,4-dihydro-3-oxoquinoxaline-1(2H)-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 0 - 20 ℃;
DOI:10.1021/ol202760c

Reference yield:

: 1345694-32-7
3,4-dihydro-4-benzyl-7-fluoro-3-oxoquinoxaline-2-carbonitrile-1-oxide

: 1345694-43-0
isopropyl 4-benzyl-2-ethyl-7-fluoro-3,4-dihydro-3-oxoquinoxaline-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / -40 °C

2: acetic acid; zinc / 4 h / 20 °C

3: sodium hydrogencarbonate / water; ethyl acetate / 0 - 20 °C

With sodium hydrogencarbonate; acetic acid; zinc; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/ol202760c

Reference yield:

: 1345694-41-8
4-benzyl-2-ethyl-7-fluoro-3-quinoxalinone-1-oxide

: 1345694-43-0
isopropyl 4-benzyl-2-ethyl-7-fluoro-3,4-dihydro-3-oxoquinoxaline-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; zinc / 4 h / 20 °C

2: sodium hydrogencarbonate / water; ethyl acetate / 0 - 20 °C

With sodium hydrogencarbonate; acetic acid; zinc; In water; ethyl acetate;
DOI:10.1021/ol202760c