2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid

Base Information

Chemical Name:2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid
CAS No.:1354721-84-8
Molecular Formula:C₃₃H₂₄ClF₃N₄O₄S
Molecular Weight:665.092
Hs Code.:

Synonyms:2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid

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Chemical Property of 2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid

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Technology Process of 2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid

There total 6 articles about 2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354722-34-1
C₂₅H₁₇Cl₂F₃N₄O₂

: 63271-86-3
2-(3-mercaptophenyl)acetic acid

: 1354721-84-8
2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 1354721-84-8
2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 20 °C

3.1: pyridine / 1 h / 20 °C

4.1: zinc; acetic acid / 1 h / 70 °C

4.2: pH 8

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran

5.2: 0 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; copper(l) iodide; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; L-proline; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1354722-12-5
3-nitro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole

: 1354721-84-8
2-(3-((3-((4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium on activated charcoal / methanol / 20 °C

2.1: pyridine / 1 h / 20 °C

3.1: zinc; acetic acid / 1 h / 70 °C

3.2: pH 8

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran

4.2: 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;