5-chloro-2-fluoro-3-(4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)aniline

Base Information

Chemical Name:5-chloro-2-fluoro-3-(4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)aniline
CAS No.:1269440-79-0
Molecular Formula:C₁₉H₁₉ClFN₅OS
Molecular Weight:419.91
Hs Code.:

Synonyms:5-chloro-2-fluoro-3-(4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)aniline

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Chemical Property of 5-chloro-2-fluoro-3-(4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)aniline

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Technology Process of 5-chloro-2-fluoro-3-(4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)aniline

There total 1 articles about 5-chloro-2-fluoro-3-(4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269440-79-0
5-chloro-2-fluoro-3-(4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)aniline

Guidance literature:

Reference yield:

: 1269440-79-0
5-chloro-2-fluoro-3-(4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)aniline

: 124-63-0
methanesulfonyl chloride

: 121-44-8
triethylamine

: 1269440-80-3
N-{5-chloro-2-fluoro-3-[4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]phenyl}methanesulfonamide

: 1269440-81-4
N-{5-chloro-2-fluoro-3-[4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]phenyl}-N-(methylsulfonyl)methanesulfonamide

Guidance literature:: In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1269440-79-0
5-chloro-2-fluoro-3-(4-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)aniline

: 1269440-42-7
methyl (2S)-N-[1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(oxan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 16 h / 20 °C

2.1: Oxone / tetrahydrofuran; water / 16 h / 20 °C

2.2: 16 h / 110 °C

With Oxone; In tetrahydrofuran; dichloromethane; water;