2-(2,5-Difluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane

Base Information

• Chemical Name: 2-(2,5-Difluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane
• CAS No.: 241479-70-9
• Molecular Formula: C₁₅H₁₈F₂O₃
• Molecular Weight: 284.303
• DSSTox Substance ID: DTXSID401152466
• Mol file: 241479-70-9.mol

Synonyms:241479-70-9;SCHEMBL7945489;HEVFNDSPMJBYLT-SFNBMPIDSA-N;DTXSID401152466;2-{1-[2-(2,5-Difluoro-phenyl)-oxiranyl]-ethoxy}-tetrahydro-pyran;2-[(1R)-1-[2-(2,5-Difluorophenyl)-2-oxiranyl]ethoxy]tetrahydro-2H-pyran;2-(2,5-difluorophenyl)-2-[(1r)-1-(3,4,5,6,-tetrahydro-2h-pyran-2-yloxy)ethyl]oxirane;2-(2,5-Difluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane

Chemical Property of 2-(2,5-Difluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 284.12240076
• Heavy Atom Count: 20
• Complexity: 341

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1(CO1)C2=C(C=CC(=C2)F)F)OC3CCCCO3
• Isomeric SMILES: C[C@H](C1(CO1)C2=C(C=CC(=C2)F)F)OC3CCCCO3

Technology Process of 2-(2,5-Difluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane

There total 1 articles about 2-(2,5-Difluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(2R)-2',5'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone (241479-69-6) + trimethylsulfoxonium iodide (1774-47-6) → 2-(2,5-difluorophenyl)-2-[(1R)-1-(3,4,5,6,-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane (241479-70-9)

Guidance literature:

With NaH; In dimethyl sulfoxide;

Reference yield: 73.0%

1,2,4-Triazole (288-88-0) + 2-(2,5-difluorophenyl)-2-[(1R)-1-(3,4,5,6,-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane (241479-70-9) → (3R)-2-(2,5difluorophenyl)-3-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:

With NaH; In N,N-dimethyl-formamide;

Reference yield:

2-(2,5-difluorophenyl)-2-[(1R)-1-(3,4,5,6,-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane (241479-70-9) → (R)-2-(2,5-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:

With NaH; In 1,2,3-triazole; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

(2R)-2',5'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone

trimethylsulfoxonium iodide