(2R)-1-(2,5-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one

Base Information

• Chemical Name: (2R)-1-(2,5-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one
• CAS No.: 241479-69-6
• Molecular Formula: C₁₄H₁₆F₂O₃
• Molecular Weight: 270.276
• DSSTox Substance ID: DTXSID801147136
• Mol file: 241479-69-6.mol

Synonyms:241479-69-6;(2R)-1-(2,5-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one;SCHEMBL6850704;PKRHUCFPMFLUSS-CGCSKFHYSA-N;DTXSID801147136;1-(2,5-Difluoro-phenyl)-2-(tetrahydro-pyran-2-yloxy)-propan-1-one;(2R)-1-(2,5-Difluorophenyl)-2-(tetrahydro-2h-pyran-2-yloxy)propan-1-one;(2R)-1-(2,5-Difluorophenyl)-2-[(tetrahydro-2H-pyran-2-yl)oxy]-1-propanone;(2R)-2',5'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone;(2r)-2',5'-difluoro-2-(3,4,5,6-tetrahydro-2h-pyran-2-yloxy)propiophenone

Chemical Property of (2R)-1-(2,5-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one

Chemical Property:

• Boiling Point: 367.3±42.0 °C(Predicted)
• Density: 1.21±0.1 g/cm3(Predicted)
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 270.10675069
• Heavy Atom Count: 19
• Complexity: 311

Purity/Quality:

97% ^*data from raw suppliers

(2R)-1-(2,5-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C(=O)C1=C(C=CC(=C1)F)F)OC2CCCCO2
• Isomeric SMILES: C[C@H](C(=O)C1=C(C=CC(=C1)F)F)OC2CCCCO2

Technology Process of (2R)-1-(2,5-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one

There total 8 articles about (2R)-1-(2,5-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-1,4-difluorobenzene (399-94-0) + 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine (135270-08-5) → (2R)-2',5'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone (241479-69-6)

Guidance literature:

Reference yield: 98.0%

(R)-1-(1 piperidinyl)-2-(2-tetrahydropyranyl)oxy-1-propanone + (2,5-difluorophenyl)magnesium bromide (899819-34-2) → (2R)-2',5'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone (241479-69-6)

Guidance literature:

In tetrahydrofuran; at -20 - 20 ℃; for 4.25h; Large scale;

Reference yield: 98.0%

(R)-1-(1-azetidinyl)-2-(2-tetrahydropyranyl)oxy-1-propanone + (2,5-difluorophenyl)magnesium bromide (899819-34-2) → (2R)-2',5'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone (241479-69-6)

Guidance literature:

In tetrahydrofuran; at -20 - 20 ℃; for 4.25h; Large scale;

upstream raw materials:

2-bromo-1,4-difluorobenzene

4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine

para-difluorobenzene

(2,5-difluorophenyl)magnesium bromide

Downstream raw materials:

(2R,3R)-2-(2,5-difluorophenyl)-1,2,3-butanetriol

2-(2,5-difluorophenyl)-2-[(1R)-1-(3,4,5,6,-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane

(2S,3R)-2-(2,5-difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-butan-2-ol

(2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol