(3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol

Base Information

Chemical Name:(3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol
CAS No.:959937-49-6
Molecular Formula:C₂₂H₃₉NO₄SSi
Molecular Weight:441.707
Hs Code.:

Synonyms:(3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol

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Chemical Property of (3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol

Chemical Property:

Purity/Quality:

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Technology Process of (3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol

There total 4 articles about (3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959937-50-9
(3R,6S)-6-hydroxymethyl-1-(toluene-4-sulphonyl)piperidin-3-ol

: 13154-24-0
triisopropylsilyl chloride

: 959937-49-6
(3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 42h;

Reference yield:

: 959937-51-0
benzyl (2S,5R)-5-hydroxy-6-oxopiperidine-2-carboxylate

: 959937-49-6
(3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 66 °C

1.2: 0 °C

1.3: pH > 11

2.1: hydrogenchloride; sodium carbonate / tetrahydrofuran; water / 22 h / 70 °C / pH 8

3.1: 1H-imidazole / N,N-dimethyl-formamide / 42 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 406945-58-2
1,3,4-trideoxynojirimycin

: 959937-49-6
(3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; sodium carbonate / tetrahydrofuran; water / 22 h / 70 °C / pH 8

2: 1H-imidazole / N,N-dimethyl-formamide / 42 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;