959937-50-9

Basic information

• Product Name: (3R,6S)-6-hydroxymethyl-1-(toluene-4-sulphonyl)piperidin-3-ol
• Synonyms: (3R,6S)-6-hydroxymethyl-1-(toluene-4-sulphonyl)piperidin-3-ol
• CAS NO: 959937-50-9
• Molecular Weight: 285.364
• Mol File: 959937-50-9.mol

Chemical Properties

• CAS DataBase Reference: (3R,6S)-6-hydroxymethyl-1-(toluene-4-sulphonyl)piperidin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,6S)-6-hydroxymethyl-1-(toluene-4-sulphonyl)piperidin-3-ol(959937-50-9)
• EPA Substance Registry System: (3R,6S)-6-hydroxymethyl-1-(toluene-4-sulphonyl)piperidin-3-ol(959937-50-9)

Safety Data

• Hazardous Substances Data: 959937-50-9(Hazardous Substances Data)

Upstream product

• 480460-75-1 2-benzyl 1-tert-butyl (2S,5R)-5-hydroxy-6-oxo-1,2-piperidinedicarboxylate 
• 959937-51-0 benzyl (2S,5R)-5-hydroxy-6-oxopiperidine-2-carboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 406945-58-2 1,3,4-trideoxynojirimycin 

Downstream Products

• 959937-49-6 (3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxymethylpiperidin-3-ol 
• 959937-46-3 [(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]methanol 
• 959937-43-0 [(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]acetaldehyde 
• 959937-55-4 6-[(3R,6S)-6-bromomethyl-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine 
• 959937-44-1 [(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]acetonitrile 
• 1005478-09-0 (S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol 
• 1005478-08-9 (R)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol 
• 959937-92-9 2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine 
• 959937-98-5 (R)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3-methylbutan-2-ol 
• 959937-45-2 (2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-ylmethyl methanesulphonate 
• 959937-54-3 methyl 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionate 
• 959938-03-5 6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine 
• 959937-53-2 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethyl-propionic acid 
• 1005478-45-4 1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one 

Relevant articles and documents

SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS

Use of compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R, R1 and X have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin Il and/or HIV protease inhibitors.

2,5-DISUBSTITUTED PIPERIDINES

The application relates to 2,5-disubstituted piperidines, their preparation and use as medicines, especially as renin inhibitors, of the general formula (I) in which R, R1 and X are each as defined in detail in the description, and pharmaceutical preparations comprising these compounds.