[2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

Base Information

Chemical Name:[2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine
CAS No.:425618-88-8
Molecular Formula:C₃₄H₄₀BrNO₂Si
Molecular Weight:602.687
Hs Code.:

Synonyms:[2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

Suppliers and Price of [2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

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Technology Process of [2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

There total 9 articles about [2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 425630-02-0
[2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

: 425618-88-8
[2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1002/1521-3773(20020118)41:2<348::AID-ANIE348>3.0.CO;2-I DOI:10.1021/ja0365330

Reference yield:

: 588719-69-1
2-Bromo-4-[(S)-3-hydroxy-2-(trityl-amino)-propyl]-phenol

: 425618-88-8
[2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 2.5 h / 0 °C

2: 100 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

With tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0365330

Reference yield:

: 18621-06-2
N-trityl-L-tyrosine methyl ester

: 425618-88-8
[2-[3-bromo-4-hydroxyphenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / NBS / dimethylformamide / 2.5 h / 20 °C

2: 96 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 5 h / -78 - 20 °C

3: 87 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 2.5 h / 0 °C

4: 100 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0365330