[2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

Base Information

Chemical Name:[2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine
CAS No.:425630-02-0
Molecular Formula:C₄₀H₅₄BrNO₂Si₂
Molecular Weight:716.949
Hs Code.:

Synonyms:[2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

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Chemical Property of [2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

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Technology Process of [2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

There total 8 articles about [2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 588719-69-1
2-Bromo-4-[(S)-3-hydroxy-2-(trityl-amino)-propyl]-phenol

: 425630-02-0
[2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 2.5h;
DOI:10.1039/c1ob05058c

Reference yield:

: 18621-06-2
N-trityl-L-tyrosine methyl ester

: 425630-02-0
[2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / NBS / dimethylformamide / 2.5 h / 20 °C

2: 96 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 5 h / -78 - 20 °C

3: 87 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 2.5 h / 0 °C

With N-Bromosuccinimide; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0365330

Reference yield:

: 425604-48-4
3-(3-bromo-4-hydroxyphenyl)-2-(tritylamino)propionic acid methyl ester

: 425630-02-0
[2-[3-bromo-4-(tertbutyldimethylsilyloxy)phenyl]-1-(tert-butyldimethylsilyloxymethyl)ethyl]tritylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 5 h / -78 - 20 °C

2: 87 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 2.5 h / 0 °C

With diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In hexane; dichloromethane;
DOI:10.1021/ja0365330