(2S,4R)-N-(benzyloxycarbonyl)-4-tert-butoxy-2-(hydroxymethyl)pyrrolidine

Base Information

Chemical Name:(2S,4R)-N-(benzyloxycarbonyl)-4-tert-butoxy-2-(hydroxymethyl)pyrrolidine
CAS No.:1056938-94-3
Molecular Formula:C₁₇H₂₅NO₄
Molecular Weight:307.39
Hs Code.:

Synonyms:(2S,4R)-N-(benzyloxycarbonyl)-4-tert-butoxy-2-(hydroxymethyl)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-N-(benzyloxycarbonyl)-4-tert-butoxy-2-(hydroxymethyl)pyrrolidine

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Technology Process of (2S,4R)-N-(benzyloxycarbonyl)-4-tert-butoxy-2-(hydroxymethyl)pyrrolidine

There total 3 articles about (2S,4R)-N-(benzyloxycarbonyl)-4-tert-butoxy-2-(hydroxymethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

: 146951-99-7
(2S,4R)-1-(Benzyloxycarbonyl)-4-(tert-butyloxy)-2-pyrrolidincarbonsaeure-methylester

: 1056938-94-3
(2S,4R)-N-(benzyloxycarbonyl)-4-tert-butoxy-2-(hydroxymethyl)pyrrolidine

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201101156

Reference yield:

: C₂₀H₂₇NO₇

: 1056938-94-3
(2S,4R)-N-(benzyloxycarbonyl)-4-tert-butoxy-2-(hydroxymethyl)pyrrolidine

Guidance literature:: C₂₀H₂₇NO₇; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; for 1.5h;

Reference yield:

: 541-41-3
chloroformic acid ethyl ester

: 85201-91-8
(2S,4R)-4-tert-butoxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

: 1056938-94-3
(2S,4R)-N-(benzyloxycarbonyl)-4-tert-butoxy-2-(hydroxymethyl)pyrrolidine

Guidance literature:: chloroformic acid ethyl ester; (2S,4R)-4-tert-butoxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.833333h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 1h;

With hydrogenchloride; methanol; water; In tetrahydrofuran; for 1.5h;