(2S)-N²-carbobenzoxy-N³-phthaloyl-2,3-diaminopropionic acid

Base Information

• Chemical Name: (2S)-N²-carbobenzoxy-N³-phthaloyl-2,3-diaminopropionic acid
• CAS No.: 147635-15-2
• Molecular Formula: C₁₉H₁₆N₂O₆
• Molecular Weight: 368.346
• Mol file: 147635-15-2.mol

Synonyms:(2S)-N²-carbobenzoxy-N³-phthaloyl-2,3-diaminopropionic acid

Chemical Property of (2S)-N²-carbobenzoxy-N³-phthaloyl-2,3-diaminopropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-N²-carbobenzoxy-N³-phthaloyl-2,3-diaminopropionic acid

There total 3 articles about (2S)-N²-carbobenzoxy-N³-phthaloyl-2,3-diaminopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-ethoxycarbonylphthalimide (22509-74-6) + (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid (35761-26-3) → (2S)-N2-carbobenzoxy-N3-phthaloyl-2,3-diaminopropionic acid (147635-15-2)

Guidance literature:

With sodium carbonate; at 20 ℃; for 4h;

DOI:10.1055/s-2001-16752

Reference yield:

phthalic anhydride (85-44-9) + (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid (35761-26-3) → (2S)-N2-carbobenzoxy-N3-phthaloyl-2,3-diaminopropionic acid (147635-15-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm9606453

Reference yield:

N-benzyloxycarbonyl-L-asparagine (2304-96-3) → (2S)-N2-carbobenzoxy-N3-phthaloyl-2,3-diaminopropionic acid (147635-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / (CF₃CO₂)2IC₆H₅; pyridine / dimethylformamide; H₂O

2: 75 percent / aq. Na₂CO₃ / 4 h / 20 °C

With pyridine; sodium carbonate; bis-[(trifluoroacetoxy)iodo]benzene; In water; N,N-dimethyl-formamide;

DOI:10.1055/s-2001-16752

upstream raw materials:

N-ethoxycarbonylphthalimide

(S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid

phthalic anhydride

N-benzyloxycarbonyl-L-asparagine

Downstream raw materials:

methyl 2-L--3-phthalimidopropanoate

(2S)-N²-carbobenzoxy-N²-methyl-2-amino-3-guanidinopropionic acid

(2S)-N²-carbobenzoxy-N²-methyl-2,3-diaminopropionic acid