N-cyclopropyl-3-{3-[1-(dimethylamino)-1-methylethyl]-6,8-difluoro[1,2,4]triazolo-[4,3-a]pyridin-7-yl}-5-fluoro-4-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-3-{3-[1-(dimethylamino)-1-methylethyl]-6,8-difluoro[1,2,4]triazolo-[4,3-a]pyridin-7-yl}-5-fluoro-4-methylbenzamide
CAS No.:1057394-30-5
Molecular Formula:C₂₂H₂₄F₃N₅O
Molecular Weight:431.461
Hs Code.:

Synonyms:N-cyclopropyl-3-{3-[1-(dimethylamino)-1-methylethyl]-6,8-difluoro[1,2,4]triazolo-[4,3-a]pyridin-7-yl}-5-fluoro-4-methylbenzamide

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Chemical Property of N-cyclopropyl-3-{3-[1-(dimethylamino)-1-methylethyl]-6,8-difluoro[1,2,4]triazolo-[4,3-a]pyridin-7-yl}-5-fluoro-4-methylbenzamide

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Technology Process of N-cyclopropyl-3-{3-[1-(dimethylamino)-1-methylethyl]-6,8-difluoro[1,2,4]triazolo-[4,3-a]pyridin-7-yl}-5-fluoro-4-methylbenzamide

There total 6 articles about N-cyclopropyl-3-{3-[1-(dimethylamino)-1-methylethyl]-6,8-difluoro[1,2,4]triazolo-[4,3-a]pyridin-7-yl}-5-fluoro-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 110-88-3
1,3,5-Trioxan

: 1057394-28-1
3-[3-(1-amino-1-methylethyl)-6,8-difluoro[1,2,4]triazolo[4,3-a]pyridin-7-yl]-N-cyclopropyl-5-fluoro-4-methylbenzamide

: 1057394-30-5
N-cyclopropyl-3-{3-[1-(dimethylamino)-1-methylethyl]-6,8-difluoro[1,2,4]triazolo-[4,3-a]pyridin-7-yl}-5-fluoro-4-methylbenzamide

Guidance literature:: 1,3,5-Trioxan; 3-[3-(1-amino-1-methylethyl)-6,8-difluoro[1,2,4]triazolo[4,3-a]pyridin-7-yl]-N-cyclopropyl-5-fluoro-4-methylbenzamide; With sodium triacetoxy borohydride; In 1,1-dichloroethane; at 20 ℃; for 2.5h;

With sodium hydrogencarbonate; In 1,1-dichloroethane; water;

Reference yield:

: 585544-29-2
N-cyclopropyl-5-fluoro-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide

: 1375802-21-3
C₁₁H₁₃F₂IN₄

: 1057394-30-5
N-cyclopropyl-3-{3-[1-(dimethylamino)-1-methylethyl]-6,8-difluoro[1,2,4]triazolo-[4,3-a]pyridin-7-yl}-5-fluoro-4-methylbenzamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; at 90 ℃;
DOI:10.1016/j.bmcl.2012.03.099

Reference yield:

: 1375801-97-0
C₁₁H₁₆F₂N₄O

: 1057394-30-5
N-cyclopropyl-3-{3-[1-(dimethylamino)-1-methylethyl]-6,8-difluoro[1,2,4]triazolo-[4,3-a]pyridin-7-yl}-5-fluoro-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilylazide; diethylazodicarboxylate

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; zinc(II) chloride; lithium hexamethyldisilazane / hexane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilylazide; zinc(II) chloride; lithium hexamethyldisilazane; diethylazodicarboxylate; In hexane;
DOI:10.1016/j.bmcl.2012.03.099