585544-29-2

Upstream product

• 585544-31-6 N-cyclopropyl-3-fluoro-5-iodo-4-methylbenzamide 
• 73183-34-3 bis(pinacol)diborane 
• 350-28-7 3-fluoro-4-methyl-benzoic acid 
• 65-85-0 benzoic acid 
• 918331-98-3 3-fluoro-5-iodo-4-methylbenzoyl chloride 
• 861905-94-4 3-fluoro-5-iodo-4-methylbenzoic acid 
• 515131-38-1 3 -bromo-N-cyclopropyl-5-fluoro-4-methylbenzamide 

Downstream Products

• 1188284-38-9 N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide 
• 1191988-24-5 N₃-cyclopropyl-5-fluoro-6-methyl-N₄'-(tetrahydro-2-furanyl-methyl)-3,4'-biphenyldicarboxamide 
• 585543-11-9 6-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-N-(cyclopropylmethyl)-3-pyridinecarboxamide 
• 1080572-00-4 N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-5-fluoro-4-methylbenzamide 
• 1214882-14-0 N-cyclopropyl-3-(8-(2,4-difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyridazin-3-yl)-5-fluoro-4-methylbenzamide 
• 1019916-91-6 N-cyclopropyl-3-(3-(1,1-dimethylethyl)[1,2,4]triazolo-[4,3-a]pyridin-7-yl)-5-fluoro-4-methylbenzamide 
• 1057394-12-3 N-cyclopropyl-3-fluoro-5-(3-isopropyl[1,2,4]triazolo[4,3-a]pyridin-7-yl)-4-methylbenzamide 
• 1057394-11-2 N-cyclopropyl-3-(3-cyclopropyl[1,2,4]triazolo[4,3-a]pyridin-7-yl)-5-fluoro-4-methylbenzamide 
• 1057394-31-6 N-cyclopropyl-3-fluoro-4-methyl-5-[3-(1-methylcyclopropyl)[1,2,4]triazolo[4,3-a]pyridin-7-yl]benzamid 
• 1057394-13-4 3-(3-cyclobutyl[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide 
• 1057394-14-5 N-cyclopropyl-3-fluoro-4-methyl-5-[3-(tetrahydro-2H-pyran-4-yl)[1,2,4]triazolo[4,3-a]pyridin-7-yl]benzamide 
• 1019916-93-8 3-(3-(2-chlorophenyl)[1,2,4]triazolo-[4,3-a]pyridin-7-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide 
• 1375801-75-4 C₂₀H₂₁FN₄O₂ 
• 1057394-21-4 C₁₈H₁₄F₄N₄O 

Relevant academic research and scientific papers

NOVEL COMPOUNDS HAVING EFFECTS OF TREATING INFLAMMATORY DISEASE AS P38 MAP KINASE INHIBITOR

The present invention relates to novel compounds exhibiting anti-inflammatory activity. The compound of the present invention plays a critical role in the production of inflammatory prodrug (pro-inflammatory cytokines) and has an excellent inhibitory effe

BENZAMIDE DERIVATIVE

The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R1, Z and Q are as described in the description.

NEW 7-PHENYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE DERIVATIVES

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), to processes for their preparation, to pharmaceutical compositions comprising them, and to their use in therapy.

New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), to pharmaceutical compositions comprising them, and to their use in therapy.

New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.

p38α mitogen-activated protein kinase inhibitors: Optimization of a series of biphenylamides to give a molecule suitable for clinical progression

p38α MAP kinase is a key anti-inflammatory target for rheumatoid arthritis, influencing biosynthesis of pro-inflammatory cytokines TNFα and IL-1β at a translational and transcriptional level. In this paper, we describe how we have optimized a series of no

NEW 3-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-7-YL)BENZAMIDE DERIVATIVES

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use use in therapy as CSBP/RK/p38 kinase inhibitors.

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds, and 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use use in therapy as CSBP/RK/p38 kinase inhibitors.