1-(2-hydroxy-4-methoxy-α-methylbenzylidene)-2-benzoylhydrazine

Base Information

• Chemical Name: 1-(2-hydroxy-4-methoxy-α-methylbenzylidene)-2-benzoylhydrazine
• CAS No.: 114070-33-6
• Molecular Formula: C₁₆H₁₆N₂O₃
• Molecular Weight: 284.315
• Mol file: 114070-33-6.mol

Synonyms:1-(2-hydroxy-4-methoxy-α-methylbenzylidene)-2-benzoylhydrazine

Chemical Property of 1-(2-hydroxy-4-methoxy-α-methylbenzylidene)-2-benzoylhydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-hydroxy-4-methoxy-α-methylbenzylidene)-2-benzoylhydrazine

There total 3 articles about 1-(2-hydroxy-4-methoxy-α-methylbenzylidene)-2-benzoylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) + benzoic acid hydrazide (613-94-5) → 1-(2-hydroxy-4-methoxy-α-methylbenzylidene)-2-benzoylhydrazine (114070-33-6)

Guidance literature:

In propan-1-ol; Heating; also in xylol;

DOI:10.1016/S0040-4039(00)96497-9

Reference yield:

benzoic acid (65-85-0,8013-63-6) → 1-(2-hydroxy-4-methoxy-α-methylbenzylidene)-2-benzoylhydrazine (114070-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol

3: acetic acid / methanol / 70 °C

With hydrazine hydrate; sulfuric acid; acetic acid; In methanol; ethanol;

DOI:10.1016/j.foodchem.2018.06.083

Reference yield:

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) → 1-(2-hydroxy-4-methoxy-α-methylbenzylidene)-2-benzoylhydrazine (114070-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol

2: acetic acid / methanol / 70 °C

With hydrazine hydrate; acetic acid; In methanol; ethanol;

DOI:10.1016/j.foodchem.2018.06.083

upstream raw materials:

1-(2-hydroxy-4-methoxyphenyl)ethanone

benzoic acid hydrazide

benzoic acid

benzoic acid methyl ester

Downstream raw materials:

Zn(C₆H₅COHN₂CCH₃C₆H₃OCH₃O)2

1-(2-benzoyl-4-methoxyphenyl)ethanone