2,2,2-trichloroethyl 2,5-dioxo-2,5-dihydrobenzoat

Base Information

• Chemical Name: 2,2,2-trichloroethyl 2,5-dioxo-2,5-dihydrobenzoat
• CAS No.: 115148-08-8
• Molecular Formula: C₉H₅Cl₃O₄
• Molecular Weight: 283.495
• Mol file: 115148-08-8.mol

Synonyms:2,2,2-trichloroethyl 2,5-dioxo-2,5-dihydrobenzoat

Chemical Property of 2,2,2-trichloroethyl 2,5-dioxo-2,5-dihydrobenzoat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trichloroethyl 2,5-dioxo-2,5-dihydrobenzoat

There total 2 articles about 2,2,2-trichloroethyl 2,5-dioxo-2,5-dihydrobenzoat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,5-dihydroxybenzoic acid 2,2,2-trichloroethyl ester (115148-06-6) → 2,2,2-trichloroethyl 2,5-dioxo-2,5-dihydrobenzoat (115148-08-8)

Guidance literature:

With manganese(IV) oxide; sodium sulfate; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1039/P19890000179

Reference yield:

2,5-dihydroxybenzoic acid. (490-79-9) → 2,2,2-trichloroethyl 2,5-dioxo-2,5-dihydrobenzoat (115148-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / toluene-p-sulphonic acid / toluene / 24 h / Heating

2: 89 percent / activated manganese dioxide, anhydrous sodium sulphate / CH₂Cl₂ / 0.5 h / Ambient temperature

With manganese(IV) oxide; toluene-4-sulfonic acid; sodium sulfate; In dichloromethane; toluene;

DOI:10.1039/P19890000179

Reference yield: 76.0%

(furan-2-yloxy)-trimethylsilane (61550-02-5) + 2,2,2-trichloroethyl 2,5-dioxo-2,5-dihydrobenzoat (115148-08-8) → (3aS,8bS)-7-Hydroxy-2-oxo-2,3,3a,8b-tetrahydro-benzo[b]furo[2,3-d]furan-8-carboxylic acid 2,2,2-trichloro-ethyl ester (115148-13-5)

Guidance literature:

In acetonitrile; at 0 ℃;

DOI:10.1016/S0040-4039(00)96653-X

upstream raw materials:

2,5-dihydroxybenzoic acid 2,2,2-trichloroethyl ester

2,5-dihydroxybenzoic acid.

Downstream raw materials:

(3aS,8bS)-7-Hydroxy-2-oxo-2,3,3a,8b-tetrahydro-benzo[b]furo[2,3-d]furan-8-carboxylic acid 2,2,2-trichloro-ethyl ester