1,1,1-tris<2-<6-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)hexylaminocarbonyl>ethoxymethyl>ethane

Base Information

• Chemical Name: 1,1,1-tris<2-<6-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)hexylaminocarbonyl>ethoxymethyl>ethane
• CAS No.: 219992-83-3
• Molecular Formula: C₆₅H₉₀N₁₂O₁₂
• Molecular Weight: 1231.5

Synonyms:1,1,1-tris<2-<6-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)hexylaminocarbonyl>ethoxymethyl>ethane

Chemical Property of 1,1,1-tris<2-<6-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)hexylaminocarbonyl>ethoxymethyl>ethane

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Technology Process of 1,1,1-tris<2-<6-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)hexylaminocarbonyl>ethoxymethyl>ethane

There total 4 articles about 1,1,1-tris<2-<6-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)hexylaminocarbonyl>ethoxymethyl>ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1,1,1-tris(2-succinimidooxycarbonylethoxymethyl)ethane (173414-89-6) + N-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-yl)hexane-1,6-diamine hydrochloride → 1,1,1-tris<2-<6-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)hexylaminocarbonyl>ethoxymethyl>ethane (219992-83-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 38 ℃; for 69h;

DOI:10.1039/a807159d

Reference yield:

tert-butyl N-(6-aminohexyl)carbamate (51857-17-1) → 1,1,1-tris<2-<6-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)hexylaminocarbonyl>ethoxymethyl>ethane (219992-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / tetrahydrofuran / 9 h / Heating

2: HCl / dioxane / 1 h / 0 °C

3: 54 percent / Et₃N / dimethylformamide / 69 h / 38 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1039/a807159d

Reference yield:

1-(benzyloxy)-4-(1′,2′,4′-triazol-1′-yl)-2-(1H)-pyrimidinone (219992-65-1) → 1,1,1-tris<2-<6-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)hexylaminocarbonyl>ethoxymethyl>ethane (219992-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / tetrahydrofuran / 9 h / Heating

2: HCl / dioxane / 1 h / 0 °C

3: 54 percent / Et₃N / dimethylformamide / 69 h / 38 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1039/a807159d

upstream raw materials:

1,1,1-tris(2-succinimidooxycarbonylethoxymethyl)ethane

tert-butyl N-(6-aminohexyl)carbamate

1-(benzyloxy)-4-(1′,2′,4′-triazol-1′-yl)-2-(1H)-pyrimidinone

N-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-yl)-N'-(tert-butoxycarbonyl)hexane-1,6-diamine

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