1-(2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-3-(1-benzylpiperidin-4-yl)-propan-1-one

Base Information

Chemical Name:1-(2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-3-(1-benzylpiperidin-4-yl)-propan-1-one
CAS No.:263248-20-0
Molecular Formula:C₂₇H₃₄N₂O₂
Molecular Weight:418.579
Hs Code.:

Synonyms:1-(2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-3-(1-benzylpiperidin-4-yl)-propan-1-one

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Chemical Property of 1-(2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-3-(1-benzylpiperidin-4-yl)-propan-1-one

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Technology Process of 1-(2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-3-(1-benzylpiperidin-4-yl)-propan-1-one

There total 6 articles about 1-(2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-3-(1-benzylpiperidin-4-yl)-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 100-39-0
benzyl bromide

: 160300-43-6
1-(2-acetyl-2,3,4,5-tetrahydro-1H-2-benzazepin-8-yl)-3-(piperidine-4-yl)propan-1-one

: 263248-20-0
1-(2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-3-(1-benzylpiperidin-4-yl)-propan-1-one

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2005.01.022

Reference yield:

: 849935-44-0
4-nitrobenzyl 4-(3-chloro-3-oxopropyl)piperidine-1-carboxylate

: 263248-20-0
1-(2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-3-(1-benzylpiperidin-4-yl)-propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 24 percent / AlCl₃ / CH₂Cl₂ / 12 h / 20 °C

2: 72 percent / H₂ / Pd-C / ethanol; tetrahydrofuran / 1.5 h

3: 66 percent / NaHCO₃ / acetonitrile / 5 h / 20 °C

With aluminium trichloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 1: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.01.022

Reference yield:

: 51052-79-0
3-(4-piperidinyl)propionic acid hydrochloride

: 263248-20-0
1-(2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-3-(1-benzylpiperidin-4-yl)-propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / KOH / tetrahydrofuran; H₂O / 12 h / 20 °C

2: 83 percent / thionyl chloride / 1 h / 20 °C

3: 24 percent / AlCl₃ / CH₂Cl₂ / 12 h / 20 °C

4: 72 percent / H₂ / Pd-C / ethanol; tetrahydrofuran / 1.5 h

5: 66 percent / NaHCO₃ / acetonitrile / 5 h / 20 °C

With potassium hydroxide; aluminium trichloride; thionyl chloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 3: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.01.022