Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester
• CAS No.: 130998-35-5
• Molecular Formula: C₁₇H₂₀O₆S
• Molecular Weight: 352.408
• Mol file: 130998-35-5.mol

Synonyms:Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester

Chemical Property of Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester

There total 3 articles about Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-phenol (150-76-5) → Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester (130998-35-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / Heating

2: 1N aq. H₂SO₄ / 0.83 h / Heating

3: 1.) dibutyltin oxide / 1.) benzene, reflux, 2 h, 2.) dichloromethane, reflux, 3.5 h

With di-isopropyl azodicarboxylate; sulfuric acid; di(n-butyl)tin oxide; triphenylphosphine; In tetrahydrofuran;

DOI:10.3987/COM-90-5476

Reference yield:

(R)-1,2-O-isopropylidene-3-O-(4-methoxyphenyl)glycerol (130998-32-2) → Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester (130998-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1N aq. H₂SO₄ / 0.83 h / Heating

2: 1.) dibutyltin oxide / 1.) benzene, reflux, 2 h, 2.) dichloromethane, reflux, 3.5 h

With sulfuric acid; di(n-butyl)tin oxide;

DOI:10.3987/COM-90-5476

Reference yield:

(R)-3-(p-methoxyphenoxy)-1,2-propanediol (17131-52-1,124933-35-3,131064-88-5,131064-87-4) + p-toluenesulfonyl chloride (98-59-9) → Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester (130998-35-5)

Guidance literature:

With di(n-butyl)tin oxide; Yield given. Multistep reaction; 1.) benzene, reflux, 2 h, 2.) dichloromethane, reflux, 3.5 h;

DOI:10.3987/COM-90-5476

upstream raw materials:

(R)-3-(p-methoxyphenoxy)-1,2-propanediol

p-toluenesulfonyl chloride

(R)-1,2-O-isopropylidene-3-O-(4-methoxyphenyl)glycerol

4-methoxy-phenol

Downstream raw materials:

4-methoxybenzyloxy ester of (S)-glycidol