tetrabenzyl 3-oxo-3-[(2,3-dibenzyloxyphenyl)amino]propane-1,1-bisphosphonate

Base Information

Chemical Name:tetrabenzyl 3-oxo-3-[(2,3-dibenzyloxyphenyl)amino]propane-1,1-bisphosphonate
CAS No.:740083-55-0
Molecular Formula:C₅₁H₄₉NO₉P₂
Molecular Weight:881.899
Hs Code.:

Synonyms:tetrabenzyl 3-oxo-3-[(2,3-dibenzyloxyphenyl)amino]propane-1,1-bisphosphonate

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Chemical Property of tetrabenzyl 3-oxo-3-[(2,3-dibenzyloxyphenyl)amino]propane-1,1-bisphosphonate

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Technology Process of tetrabenzyl 3-oxo-3-[(2,3-dibenzyloxyphenyl)amino]propane-1,1-bisphosphonate

There total 3 articles about tetrabenzyl 3-oxo-3-[(2,3-dibenzyloxyphenyl)amino]propane-1,1-bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 183383-58-6
3,3-bis(dibenzyloxyphosphoryl)propanoic acid

: 2,3-bis(benzyloxy)benzenamine

: 740083-55-0
tetrabenzyl 3-oxo-3-[(2,3-dibenzyloxyphenyl)amino]propane-1,1-bisphosphonate

Guidance literature:: 3,3-bis(dibenzyloxyphosphoryl)propanoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -8 ℃; for 0.333333h;

2,3-bis(benzyloxy)benzenamine; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1002/hc.20013

Reference yield:

: 133918-47-5
tetrabenzyl methylenediphosphonate

: 740083-55-0
tetrabenzyl 3-oxo-3-[(2,3-dibenzyloxyphenyl)amino]propane-1,1-bisphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran

2.1: CF₃COOH / CH₂Cl₂

3.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -8 °C

3.2: 57 percent / tetrahydrofuran / 0.5 h / 20 °C

With 4-methyl-morpholine; sodium hydride; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hc.20013

Reference yield:

: 183383-55-3
tetrabenzyl 2-t-butoxycarbonylethane-1,1-diphosphonate

: 740083-55-0
tetrabenzyl 3-oxo-3-[(2,3-dibenzyloxyphenyl)amino]propane-1,1-bisphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: CF₃COOH / CH₂Cl₂

2.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -8 °C

2.2: 57 percent / tetrahydrofuran / 0.5 h / 20 °C

With 4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hc.20013