N-{2-[5,6-dimethoxy-2-(tributylstannylethynyl)-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-{2-[5,6-dimethoxy-2-(tributylstannylethynyl)-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide
• CAS No.: 473840-72-1
• Molecular Formula: C₄₆H₇₁NO₅SSiSn
• Molecular Weight: 896.935
• Mol file: 473840-72-1.mol

Synonyms:N-{2-[5,6-dimethoxy-2-(tributylstannylethynyl)-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide

Chemical Property of N-{2-[5,6-dimethoxy-2-(tributylstannylethynyl)-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{2-[5,6-dimethoxy-2-(tributylstannylethynyl)-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide

There total 1 articles about N-{2-[5,6-dimethoxy-2-(tributylstannylethynyl)-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tributyltin chloride (1461-22-9) + N-{2-[2-ethynyl-5,6-dimethoxy-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide (478910-88-2) → N-{2-[5,6-dimethoxy-2-(tributylstannylethynyl)-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide (473840-72-1)

Guidance literature:

With CH₃CH₂CH₂CH₂Li; In not given;

DOI:10.1021/ja0277430

Reference yield:

N-{2-[5,6-dimethoxy-2-(tributylstannylethynyl)-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide (473840-72-1) → 5,6-dimethoxy-1-(toluene-4-sulfonyl)-9-(triisopropylsilanyloxy)-2,3-dihydro-1H-azacyclohepta[a]acenaphthylene (473840-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / -40 °C

2: LiNTMS₂ / 1,2-dimethoxy-ethane / -40 °C

With lithium hexamethyldisilazane; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1021/ja0277430

Reference yield:

oxy>iodo>benzene (129540-75-6) + N-{2-[5,6-dimethoxy-2-(tributylstannylethynyl)-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide (473840-72-1) → {5,6-dimethoxy-3-[2-(toluene-4-sulfonylamino)-ethyl]-4'-triisopropylsilanyloxy-biphenyl-2-ylethynyl}-phenyl-iodonium; trifluoro-methanesulfonate

Guidance literature:

In dichloromethane; at -40 ℃;

DOI:10.1021/ja0277430

upstream raw materials:

tributyltin chloride

N-{2-[2-ethynyl-5,6-dimethoxy-4'-(triisopropylsilanyloxy)biphenyl-3-yl]ethyl}-4-methylbenzenesulfonamide

Downstream raw materials:

5,6-dimethoxy-1-(toluene-4-sulfonyl)-9-(triisopropylsilanyloxy)-2,3-dihydro-1H-azacyclohepta[a]acenaphthylene