Technology Process of C17H23NO4
There total 4 articles about C17H23NO4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 1.25h;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 0.583333h;
DOI:10.1002/jccs.201100637
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / -78 °C
2.1: methyllithium / diethyl ether / 15 h / 0 °C
2.2: 1 h / 20 °C
2.3: 2.33 h / -78 - 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 25 °C
4.1: toluene-4-sulfonic acid / methanol / 3 h / 25 °C
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.25 h / -78 °C
5.2: 0.58 h / 0 °C
With
oxalyl dichloride; methyllithium; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
1.1: Swern oxidation / 5.1: Swern oxidation / 5.2: Swern oxidation;
DOI:10.1002/jccs.201100637
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.67 h / 25 °C
2.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / -78 °C
3.1: methyllithium / diethyl ether / 15 h / 0 °C
3.2: 1 h / 20 °C
3.3: 2.33 h / -78 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 25 °C
5.1: toluene-4-sulfonic acid / methanol / 3 h / 25 °C
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.25 h / -78 °C
6.2: 0.58 h / 0 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; methyllithium; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
2.1: Swern oxidation / 6.1: Swern oxidation / 6.2: Swern oxidation;
DOI:10.1002/jccs.201100637
