(1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester
CAS No.:1042338-95-3
Molecular Formula:C₁₇H₂₅NO₄
Molecular Weight:307.39
Hs Code.:

Synonyms:(1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester

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Chemical Property of (1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester

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Technology Process of (1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester

There total 4 articles about (1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1417733-92-6
(2R,3R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)-pent-4-en-1-yl acetate

: 1042338-95-3
(1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 3h;
DOI:10.5012/bkcs.2012.33.11.3895

Reference yield: 83.0%

: 1042338-81-7
(4R,6R)-4-(1-benzyloxyallyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 1042338-95-3
(1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 25 ℃; for 3h;
DOI:10.1002/jccs.201100637

Reference yield:

: 95715-85-8
2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester

: 1042338-95-3
(1R,2R)-(2-benzyloxy-1-hydroxymethyl-but-3-enyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate / acetone / 3 h / 25 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.67 h / 25 °C

3.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / -78 °C

4.1: methyllithium / diethyl ether / 15 h / 0 °C

4.2: 1 h / 20 °C

4.3: 2.33 h / -78 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 25 °C

6.1: toluene-4-sulfonic acid / methanol / 3 h / 25 °C

With lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; methyllithium; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil; 3.1: Swern oxidation;
DOI:10.1002/jccs.201100637