{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid

Base Information

Chemical Name:{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid
CAS No.:454185-91-2
Molecular Formula:C₂₄H₃₄O₅Si
Molecular Weight:430.616
Hs Code.:

{4-[5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid

Synonyms:{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid

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Chemical Property of {4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid

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Technology Process of {4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid

There total 10 articles about {4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 454185-97-8
{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester

: 454185-91-2
{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;
DOI:10.1021/ol0261635

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 454185-91-2
{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / -40 °C

2.1: 85 percent / potassium acetate; PdCl₂(dppf) / dioxane / 80 °C

3.1: diethanolamine / propan-2-ol; diethyl ether

3.2: hydrochloric acid / H₂O; tetrahydrofuran / 20 °C

4.1: 57 percent / copper(II) acetate; pyridine; molecular sieves 4 Angstroem / CH₂Cl₂ / 48 h / 20 °C

5.1: 100 percent / lithium hydroxide / methanol; tetrahydrofuran; H₂O / 2 h / 20 °C

With pyridine; 2,6-dimethylpyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide; 4 A molecular sieve; potassium acetate; copper diacetate; 2,2'-iminobis[ethanol]; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/ol0261635

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 454185-91-2
{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / potassium carbonate / dimethylsulfoxide / 12 h / 55 °C

2.1: 98 percent / sodium borohydride / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: 95 percent / imidazole / dimethylformamide / 12 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran / 12 h / -78 - 20 °C

4.2: 82 percent / hydrogen peroxide / tetrahydrofuran / 24 h / 20 °C

5.1: 57 percent / copper(II) acetate; pyridine; molecular sieves 4 Angstroem / CH₂Cl₂ / 48 h / 20 °C

6.1: 100 percent / lithium hydroxide / methanol; tetrahydrofuran; H₂O / 2 h / 20 °C

With pyridine; 1H-imidazole; lithium hydroxide; sodium tetrahydroborate; n-butyllithium; 4 A molecular sieve; copper diacetate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ol0261635