2-benzoyl-3-(4-chlorophenyl)-4,9-dihydronaphtho[2,3-b]furane-4,9-dione

Base Information

• Chemical Name: 2-benzoyl-3-(4-chlorophenyl)-4,9-dihydronaphtho[2,3-b]furane-4,9-dione
• CAS No.: 1327369-11-8
• Molecular Formula: C₂₅H₁₃ClO₄
• Molecular Weight: 412.829
• Mol file: 1327369-11-8.mol

Synonyms:2-benzoyl-3-(4-chlorophenyl)-4,9-dihydronaphtho[2,3-b]furane-4,9-dione

Chemical Property of 2-benzoyl-3-(4-chlorophenyl)-4,9-dihydronaphtho[2,3-b]furane-4,9-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzoyl-3-(4-chlorophenyl)-4,9-dihydronaphtho[2,3-b]furane-4,9-dione

There total 4 articles about 2-benzoyl-3-(4-chlorophenyl)-4,9-dihydronaphtho[2,3-b]furane-4,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-hydroxynaphtho-1,4-quinone (83-72-7) + N-phenacylpyridinium bromide (16883-69-5) + 4-chlorobenzaldehyde (104-88-1) → 2-benzoyl-3-(4-chlorophenyl)-4,9-dihydronaphtho[2,3-b]furane-4,9-dione (1327369-11-8)

Guidance literature:

With ammonium acetate; In water; at 130 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1039/c0gc00952k

Reference yield: 73.0%

3-(4-chlorophenyl)-1-phenylprop-2-en-1-one (956-04-7) + 2-hydroxynaphtho-1,4-quinone (83-72-7) → 2-benzoyl-3-(4-chlorophenyl)-4,9-dihydronaphtho[2,3-b]furane-4,9-dione (1327369-11-8)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; N-iodo-succinimide; In acetonitrile; at 100 ℃; for 12h; Sealed tube;

DOI:10.1002/ejoc.201601291

Reference yield:

3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 2-benzoyl-3-(4-chlorophenyl)-4,9-dihydronaphtho[2,3-b]furane-4,9-dione (1327369-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate; oxygen / tert-butyl alcohol / 2 h

2: 10 mol% palladium on carbon; caesium carbonate / N,N-dimethyl acetamide / 48 h / 130 °C / 760.05 Torr / Inert atmosphere

With 10 mol% palladium on carbon; potassium tert-butylate; oxygen; caesium carbonate; In N,N-dimethyl acetamide; tert-butyl alcohol;

DOI:10.1039/c8cc09369e

upstream raw materials:

2-hydroxynaphtho-1,4-quinone

N-phenacylpyridinium bromide

4-chlorobenzaldehyde

3-(4-chlorophenyl)-1-phenylprop-2-en-1-one