ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)hydrazino]phenylpropionate

Base Information

• Chemical Name: ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)hydrazino]phenylpropionate
• CAS No.: 401649-17-0
• Molecular Formula: C₂₂H₂₂N₂O₄
• Molecular Weight: 378.428
• Mol file: 401649-17-0.mol

Synonyms:ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)hydrazino]phenylpropionate

Chemical Property of ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)hydrazino]phenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)hydrazino]phenylpropionate

There total 4 articles about ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)hydrazino]phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

6-amino-4,7-dimethylcoumarin (29001-25-0) + Ethyl 2-benzylacetoacetate (620-79-1) → ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)hydrazino]phenylpropionate (401649-17-0)

Guidance literature:

6-amino-4,7-dimethylcoumarin; With hydrogenchloride; acetic acid; sodium nitrite; In water; at 0 ℃; for 1h;

Ethyl 2-benzylacetoacetate; With sodium acetate trihydrate; acetic acid; In water; at 0 - 5 ℃; for 6h; pH=5.5;

Reference yield:

6-amino-4,7-dimethylcoumarin (29001-25-0) → ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)hydrazino]phenylpropionate (401649-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. HCl; NaNO₂; AcOH / 2 h / 5 °C

1.2: AcONa*3H₂O; AcOH / 10 h / 20 °C / pH 5.5

2.1: 13 g / aq. HCl / 3 h

With hydrogenchloride; acetic acid; sodium nitrite;

DOI:10.1007/s10593-005-0069-8

Reference yield:

Ethyl 2-benzylacetoacetate (620-79-1) → ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)hydrazino]phenylpropionate (401649-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. HCl; NaNO₂; AcOH / 2 h / 5 °C

1.2: AcONa*3H₂O; AcOH / 10 h / 20 °C / pH 5.5

2.1: 13 g / aq. HCl / 3 h

With hydrogenchloride; acetic acid; sodium nitrite;

DOI:10.1007/s10593-005-0069-8

upstream raw materials:

6-amino-4,7-dimethylcoumarin

Ethyl 2-benzylacetoacetate