(S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

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Chemical Name:(S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
CAS No.:107942-01-8
Molecular Formula:C₄₈H₇₇N₅O₇
Molecular Weight:836.169
Hs Code.:

(S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Synonyms:(S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

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Chemical Property of (S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

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Technology Process of (S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

There total 12 articles about (S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.2%

: 107941-93-5
N,N-dioctyl-O-tert-butyltyrosylglycylglycylphenylalanylleucine methyl ester

: 107942-01-8
(S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 25 ℃; for 5.75h;
DOI:10.1021/jm00390a005

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 107942-01-8
(S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF

2: ammonium formate / 10percent Pd/C / methanol

3: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF

4: 91.9 percent / ammonium formate, H₂ / 10percent Pd/C / methanol / 0.67 h

5: 32.8 percent / N,N-diisopropylethylamine / toluene / 4 h / Heating

6: 67.2 percent / 0.25 N NaOH / tetrahydrofuran / 5.75 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; ammonium formate; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm00390a005

Reference yield:

: 3850-45-1
Cbz-L-Phe-L-Leu-OMe

: 107942-01-8
(S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dioctylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium formate / 10percent Pd/C / methanol

2: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF

3: 91.9 percent / ammonium formate, H₂ / 10percent Pd/C / methanol / 0.67 h

4: 32.8 percent / N,N-diisopropylethylamine / toluene / 4 h / Heating

5: 67.2 percent / 0.25 N NaOH / tetrahydrofuran / 5.75 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; ammonium formate; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm00390a005