{2-[4-(5-para-tolyl-3-trifluoromethylpyrazol-1-yl)benzenesulfonylamino]ethyl}carbamic acid tert-butyl ester

Base Information

• Chemical Name: {2-[4-(5-para-tolyl-3-trifluoromethylpyrazol-1-yl)benzenesulfonylamino]ethyl}carbamic acid tert-butyl ester
• CAS No.: 1416368-39-2
• Molecular Formula: C₂₄H₂₇F₃N₄O₄S
• Molecular Weight: 524.564
• Mol file: 1416368-39-2.mol

Synonyms:{2-[4-(5-para-tolyl-3-trifluoromethylpyrazol-1-yl)benzenesulfonylamino]ethyl}carbamic acid tert-butyl ester

Chemical Property of {2-[4-(5-para-tolyl-3-trifluoromethylpyrazol-1-yl)benzenesulfonylamino]ethyl}carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of {2-[4-(5-para-tolyl-3-trifluoromethylpyrazol-1-yl)benzenesulfonylamino]ethyl}carbamic acid tert-butyl ester

There total 1 articles about {2-[4-(5-para-tolyl-3-trifluoromethylpyrazol-1-yl)benzenesulfonylamino]ethyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-BOC-1,2-diaminoethane (57260-73-8) + 4-[5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonyl chloride (190711-56-9) → {2-[4-(5-para-tolyl-3-trifluoromethylpyrazol-1-yl)benzenesulfonylamino]ethyl}carbamic acid tert-butyl ester (1416368-39-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.1002/cmdc.201500287

Reference yield:

{2-[4-(5-para-tolyl-3-trifluoromethylpyrazol-1-yl)benzenesulfonylamino]ethyl}carbamic acid tert-butyl ester (1416368-39-2) → N-(2-aminoethyl)-4-[5-(4-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃;

DOI:10.1016/j.bmcl.2012.10.131

Reference yield:

{2-[4-(5-para-tolyl-3-trifluoromethylpyrazol-1-yl)benzenesulfonylamino]ethyl}carbamic acid tert-butyl ester (1416368-39-2) → C31H30F3N5O4S2 (1416368-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 25 °C

2.1: triethylamine / dichloromethane / 0.08 h / 25 °C / Inert atmosphere

2.2: 6 h / 25 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2012.10.131

upstream raw materials:

N-BOC-1,2-diaminoethane

4-[5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonyl chloride

Downstream raw materials:

C₃₁H₃₀F₃N₅O₄S₂

C₄₇H₄₇F₃N₆O₄S