2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide

Base Information

Chemical Name:2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide
CAS No.:1618646-54-0
Molecular Formula:C₂₇H₂₈N₄OS
Molecular Weight:456.612
Hs Code.:

Synonyms:2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide

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Chemical Property of 2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide

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Technology Process of 2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide

There total 4 articles about 2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1618648-02-4
{1-[4-({[2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carbonyl]amino}methyl)phenyl]cyclopropyl}carbamic acid benzyl ester

: 1618646-54-0
2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 5h; under 760.051 Torr;

Reference yield:

: 1618647-84-9
1-[(2-phenylthiazol-4-yl)methyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 1618646-54-0
2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol / 72 h / 90 °C / Inert atmosphere

2: benzotriazol-1-ol; triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

3: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; triethylamine; sodium hydroxide; In methanol; ethanol; dichloromethane;

Reference yield:

: 1618647-85-0
2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid

: 1618646-54-0
2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; triethylamine; In methanol; dichloromethane;