2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid

Base Information

• Chemical Name: 2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid
• CAS No.: 1618647-85-0
• Molecular Formula: C₁₇H₁₆N₂O₂S
• Molecular Weight: 312.392
• Mol file: 1618647-85-0.mol

Synonyms:2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid

Chemical Property of 2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid

There total 2 articles about 2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-[(2-phenylthiazol-4-yl)methyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester (1618647-84-9) → 2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid (1618647-85-0)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 90 ℃; for 72h; Inert atmosphere;

Reference yield:

ethyl 2-acetyl-4-oxopentanoate (41892-81-3) → 2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid (1618647-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 4 h / Inert atmosphere; Reflux

2: sodium hydroxide; water / ethanol / 72 h / 90 °C / Inert atmosphere

With water; toluene-4-sulfonic acid; sodium hydroxide; In ethanol; toluene;

Reference yield: 85.0%

2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid (1618647-85-0) + tert-butyl 4-(aminomethyl)benzylcarbamate (108468-00-4) → [4-({[2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carbonyl]amino}methyl)-benzyl]carbamic acid tert-butyl ester (1618647-86-1)

Guidance literature:

With benzotriazol-1-ol; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h; Inert atmosphere;

upstream raw materials:

1-[(2-phenylthiazol-4-yl)methyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

ethyl 2-acetyl-4-oxopentanoate

Downstream raw materials:

2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-(1-aminocyclopropyl)benzylamide

2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-benzylamide

[4-({[2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carbonyl]amino}methyl)-benzyl]carbamic acid tert-butyl ester

2,5-dimethyl-1-(2-phenylthiazol-4-ylmethyl)-1H-pyrrole-3-carboxylic acid 4-aminomethyl-2-methylbenzylamide