Hydroxypropyl methyl cellulose

Base Information

• Chemical Name: Hydroxypropyl methyl cellulose
• CAS No.: 9004-65-3
• Molecular Formula: C3H7O*
• Molecular Weight: 59.08708
• Hs Code.: 3912.39
• Mol file: 9004-65-3.mol

Synonyms:Metolose SH;DP 1208;Noigel 0215H;Methocel 20-333;Methocel 311;Viscontran MHPC 50;59029-31-1;HPMC;37341-76-7;Methocel 227;Methocel E;Benecel MP 943;Methocel 40-202;Methocel J;Goniosol;62683-26-5;Hypromellose;Methocel 856N;MC 400;Metolose;Accel R 100;Marpolose 60MP5;(HYDROXYPROPYL)METHYL CELLULOSE;Hydroxy?Propyl?Methyl?Cellulose;HYDROXYPROPYLMETHYL CELLULOSE(HPMC);HPMC-Industrial grade;Cellulose ether for PVC -Hydroxypropylmethylcellulose;2-HydroxyPropylMethylEther(Cellulos);Methyl Hydroxy Propyl Cellulose;hydroxypropyl methyl cellulose(HPMC);Hydroxypropylmethylcellulose;Hydroxypropyl methyl cellulose (HPMC);HPMC (Hydroxypropyl Methyl cellulose);Hydroxypropyl Methyl Cellulose;;HYDROXY PROPYL METHYL CELLULOSE??? (HPMC);Hydroxy propyl methyl cellulose;Hydroxymethyl propyl cellulose;Hydroxypropyl Methyl Cellulose(HPMC or MHPC);2-Hydroxypropyl methyl cellulose;Marpolose MP 4000;Synchron-Oral;Methylhydroxypropylcellulosum;Hypromellosum [Latin];Methocel MK 4;Isopto Frin;Culminal 20000PFR;Methofas PM;8063-82-9;137397-89-8;Hipromelosa [Spanish];Cesca HPC 50;Marpolose EMP-H;Pharmacoat 645;Isopto Tears;HPMC(Hydroxypropyl methyl cellulose);Hpmcd;Benecel MP 943W;71373-07-4;137397-91-2;171544-38-0;Estivin II;Methocel E, F, J, K;HPMC 20000PV;Methocel HG;Walocel MK 3.000PF;Methyl hydroxypropyl cellulose;Methocel F;DP 1209;Marpolose 90MP4000;Isopto alkaline;TC 5 (cellulose derivative);Hydroxypropylmethylcellulosum;Marpolose 65MP400;Walocel MW 60GA;Methocel 228;Courlose HPM;Pharmacoat 606;65607-39-8;TC 5E;Methocel E,F,K;Tearisol;Carbohydrate gum;HPM 100DS;Hipromelosa [INN-Spanish];125053-98-7;39363-71-8;Pharmacoat 603;Pharmacoat HPMC 615;Marpolose 90MP15000;Celacol HPM 5000;MOPTs;Celacol HPM 450;12673-53-9;Ultra Tears;137397-90-1;Methocel 240S;Marpolose 65MP4000;Cellulose,ethers,2-hydroxypropyl methyl ether;Benecel MP 363C;Isopto plain;Cellulose hydroxypropyl methyl ether;Methocel 20-231;Hydroxypropyl methylcellulose;Culminal MHPC;CELLULOSE, 2-HYDROXYPROPYL METHYL ETHER (R=CH3; (CH3)2CH);68073-10-9;Methocel 4FM-PRG;Cellulose, 2-hydroxypropyl methyl ether;Hydroxypropyl methylcellulose 1828;Synchron;EM 1100 (cellulose derivative);TC 5R;11106-33-5;Tears Naturale;Methyl cellulose, propylene glycol ether;2-Hydroxypropyl cellulose methyl ether;Methocel K;Hypromellosum [INN-Latin];

Chemical Property of Hydroxypropyl methyl cellulose

Chemical Property:

• Appearance/Colour: white to off-white powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 1.39
• Boiling Point: 1101.5°C at 760 mmHg
• Flash Point: 619.9°C
• PSA: 0.00000
• Density: 1.39
• LogP: 0.00000
• Storage Temp.: room temp
• Solubility.: H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow
• Water Solubility.: SOLUBLE

Purity/Quality:

98% ^*data from raw suppliers

Hypromellose ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Introduction: (Hydroxypropyl)methyl cellulose (HPMC) is a cellulose derivative widely used in drug formulations, particularly in ophthalmologic formulations due to its water solubility, biocompatibility, transparency, and rheological properties.
• Production and History: HPMC production began in the US in the late 1940s. It is a chemical derivative of cellulose, obtained through reactions with chloromethane and propylene oxide.
• Properties: HPMC is a white/creamy-white, odorless, tasteless, fibrous/granular, and nontoxic powder. It is partly O-methylated and O-(2-hydroxypropylated) cellulose. Its solubility properties, thermo-plasticity, and wide range of viscosity grades make it versatile for various applications.
• Applications: HPMC has diverse applications in industries such as food, medicine, agriculture, construction, chemicals, and textiles. It serves as a tackifier, stabilizer, emulsifier, solubilizer, binder, film-forming/coating agent, dispersant, modified-release agent, and shell material.
• Formulation and Use: In pharmaceuticals, HPMC is widely used as a physical property modifier due to its solubility in cold water and organic solvents, reversible sol-gel transformation with temperature, low hygroscopicity, high glass transition temperature, and excellent plastic deformability and compatibility. It is commonly used in tablet formulations as a binder.
• Blending with Other Polymers: To address limitations such as high cost and low oxygen-barrier property, HPMC is often blended with other polymers. For example, blending with hydroxypropyl starch (HPS) improves gas barrier properties and reduces costs, making it suitable for various applications including edible films.
• Regulatory Approval: HPMC is accepted by regulatory authorities such as the Food and Drug Administration (FDA) for use as an "inactive ingredient" in pharmaceutical formulations and as an additive in foods intended for human consumption.