4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-en-(E)-ylidenemethyl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-en-(E)-ylidenemethyl]-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1203556-28-8
Molecular Formula:C₂₆H₃₅NO₄
Molecular Weight:425.568
Hs Code.:

Synonyms:4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-en-(E)-ylidenemethyl]-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-en-(E)-ylidenemethyl]-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-en-(E)-ylidenemethyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 3 articles about 4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-en-(E)-ylidenemethyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84629-38-9
3-methoxy-2-(2,4,6-trimethylphenyl)-cyclopent-2-en-1-one

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 1203556-28-8
4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-en-(E)-ylidenemethyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 3-methoxy-2-(2,4,6-trimethylphenyl)-cyclopent-2-en-1-one; With lithium diisopropyl amide; In tetrahydrofuran; hexane; ethylbenzene; at -78 ℃; for 1h; Inert atmosphere;

tert butyl 4-formylpiperidine-1-carboxylate; In tetrahydrofuran; hexane; ethylbenzene; at -78 - 20 ℃; for 1.5h;

With potassium tert-butylate; In tetrahydrofuran; hexane; ethylbenzene; at 20 ℃; for 2h;

Reference yield:

: 5980-97-2
mesitylboronic acid

: 1203556-28-8
4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-en-(E)-ylidenemethyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 4 h / 90 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran; ethylbenzene / 1 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 - 20 °C

2.3: 2 h / 20 °C

With potassium phosphate; lithium hexamethyldisilazane; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; hexane; ethylbenzene; toluene;

Reference yield:

: 14203-25-9
2-bromo-3-methoxy-cyclopent-2-en-1-one

: 1203556-28-8
4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-en-(E)-ylidenemethyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 4 h / 90 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran; ethylbenzene / 1 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 - 20 °C

2.3: 2 h / 20 °C

With potassium phosphate; lithium hexamethyldisilazane; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; hexane; ethylbenzene; toluene;